Impact of enzymatic reduction on bivalent bispecific antibody fragmentation and loss of product purity upon reoxidation.

Impact of enzymatic reduction on bivalent bispecific antibody fragmentation and loss of product purity upon reoxidation.

Antibody disulfide bond (DSB) reduction during the manufacturing process is a widely observed phenomenon is associated with the host cell reductase is present in the liquid cell culture harvest. Induced enzyme leads to a reduction in antibodies against fragments and aggregate products that increase the load of impurities in the purification process. The impact of the decline in the bivalent bispecific antibody (BisAbs), which are increasingly entering the clinic, unexplored. We focus on the reduction and reoxidation properties homologous library BisAb format has an additional bivalent Fv (scFv) single chain fragment with engineered DSBs.

Despite all BisAbs have the same susceptibility to enzymatic reduction, fragmentation pathway relies on scFv fusion site. reduced molecules were allowed to reoxidize with and without low pH virus inactivation treatment. Both studies indicate that some species reoxidation BisAb complex formed as a result of mis-pairing DSB. In addition, the aggregate rate of increase for all molecules when there is a low pH treatment is applied. Combined, our results suggest that complex DSB mis-pairing occurs during the downstream process while aggregate formation depends on sample treatment. These results are applicable to other novel mAb-like format containing engineered DSBs, thus highlighting the need to prevent the reduction of new protein therapeutics to avoid reduced product quality during manufacturing. This article is protected by copyright. All rights reserved.


biopharmaceutical drugs are complex molecules derived from living organisms (plant or animal cells) and may contain components of living organisms using biotechnology. Biosimilars are closely similar to biopharmaceutical products that have been approved to establish a new generation of drugs that are widely available at reasonable costs.

Expiration of the patent and data protection Remicade (infliximab) aggravated acceptance biosimilar on the open market. Analysis of the data package submitted for biosimilar infliximab and assessment report published by the institute show the importance of the European Medicines Agency (EMA) product-specific guidelines (monoclonal antibody) which is being followed by different regulatory agencies around the world.

Given the use of case-by-case basis for the development of a biosimilar, infliximab biosimilar product-evaluation reports indicate similarities in the nature and extent of the data required in analytical studies, nonclinical, clinical and even utilize different cell lines of this reference product

 Impact of enzymatic reduction on bivalent bispecific antibody fragmentation and loss of product purity upon reoxidation.
Impact of enzymatic reduction on bivalent bispecific antibody fragmentation and loss of product purity upon reoxidation.

Implementation of High-Resolution LC / MS Methods in Laboratory Quality Control for Release and Stability Testing Antibodies Commercial Products.

liquid chromatography / mass spectrometry (LC / MS) has been widely used throughout the biotherapeutic development. However, the implementation of GMP-compliant commercial quality control (QC) laboratory remains a challenge. In this publication, we describe the co-validation and implementation of automated, high-throughput, and GMP compliant subunit LC / MS method to monitor antibody oxidation for commercial product release and stability testing.

DcR1 Polyclonal Antibody

ABP53214-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of DcR1 from Human. This DcR1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human DcR1

DcR1 Polyclonal Antibody

ABP53214-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of DcR1 from Human. This DcR1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human DcR1

DcR1 Polyclonal Antibody

ABP53214-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of DcR1 from Human. This DcR1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human DcR1

DcR1 Polyclonal Antibody

41854 100ul
EUR 319

DcR1 Polyclonal Antibody

41854-100ul 100ul
EUR 302.4

DcR1 Polyclonal Antibody

41854-50ul 50ul
EUR 224.4

DcR1 Polyclonal Antibody

E041854 100μg/100μl
EUR 255
Description: Available in various conjugation types.

DcR1 Polyclonal Antibody

E20-75483 100ug
EUR 225
Description: Available in various conjugation types.

DcR1 Polyclonal Antibody

E44H06925 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

DcR1 Polyclonal Antibody

BT-AP02524-100ul 100ul Ask for price
Description: TNF receptor superfamily member 10c encoded by TNFRSF10C is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.

DcR1 Polyclonal Antibody

BT-AP02524-20ul 20ul Ask for price
Description: TNF receptor superfamily member 10c encoded by TNFRSF10C is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.

DcR1 Polyclonal Antibody

BT-AP02524-50ul 50ul Ask for price
Description: TNF receptor superfamily member 10c encoded by TNFRSF10C is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.

DcR1 Polyclonal Antibody

MBS9246099-01mL 0.1mL
EUR 415

DcR1 Polyclonal Antibody

MBS9246099-5x01mL 5x0.1mL
EUR 1841

DcR1 Polyclonal Antibody

MBS9407847-005mL 0.05mL
EUR 245

DcR1 Polyclonal Antibody

MBS9407847-01mL 0.1mL
EUR 305

DcR1 Polyclonal Antibody

MBS9407847-5x01mL 5x0.1mL
EUR 1230

DcR1 Polyclonal Antibody

MBS8526464-01mg 0.1mg
EUR 305

DcR1 Polyclonal Antibody

MBS8526464-01mLAF405L 0.1mL(AF405L)
EUR 465

DcR1 Polyclonal Antibody

MBS8526464-01mLAF405S 0.1mL(AF405S)
EUR 465

DcR1 Polyclonal Antibody

MBS8526464-01mLAF610 0.1mL(AF610)
EUR 465

DcR1 Polyclonal Antibody

MBS8526464-01mLAF635 0.1mL(AF635)
EUR 465

DcR1 Polyclonal Antibody

MBS2535049-002mL 0.02mL
EUR 140

DcR1 Polyclonal Antibody

MBS2535049-006mL 0.06mL
EUR 180

DcR1 Polyclonal Antibody

MBS2535049-012mL 0.12mL
EUR 260

DcR1 Polyclonal Antibody

MBS2535049-02mL 0.2mL
EUR 405

Polyclonal DcR1 Antibody

APR06257G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human DcR1 . This antibody is tested and proven to work in the following applications:

Polyclonal DcR1 Antibody

APR06270G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human DcR1 . This antibody is tested and proven to work in the following applications:

DcR1 Polyclonal Conjugated Antibody

C41854 100ul
EUR 476.4

DcR1 Polyclonal Conjugated Antibody

MBS9450353-01mLAF350 0.1mL(AF350)
EUR 480

DcR1 Polyclonal Conjugated Antibody

MBS9450353-01mLAF405 0.1mL(AF405)
EUR 480

DcR1 Polyclonal Conjugated Antibody

MBS9450353-01mLAF488 0.1mL(AF488)
EUR 480

DcR1 Polyclonal Conjugated Antibody

MBS9450353-01mLAF555 0.1mL(AF555)
EUR 480

DcR1 Polyclonal Conjugated Antibody

MBS9450353-01mLBiotin 0.1mL(Biotin)
EUR 480

Rabbit anti-Schizosaccharomyces pombe (strain 972/ATCC 24843)(Fission yeast) DCR1 Polyclonal Antibody

MBS7187573-INQUIRE INQUIRE Ask for price

DcR1 (TNFRSF10C) goat polyclonal antibody

GT15062-100 100 µg Ask for price

DcR3 Rabbit Polyclonal Antibody

ES2152-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against DcR3 from Human. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

DcR3 Rabbit Polyclonal Antibody

ES2152-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against DcR3 from Human. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Rabbit Polyclonal DcR2 Antibody

TA305975 100 µg Ask for price

Rabbit Polyclonal DcR3 Antibody

TA306004 100 µg Ask for price

Anti-DcR1/TRAILR3 Antibody, Rabbit Polyclonal

MBS8102731-01mL 0.1mL
EUR 300

Anti-DcR1/TRAILR3 Antibody, Rabbit Polyclonal

MBS8102731-5x01mL 5x0.1mL
EUR 1200

Anti-DcR1/TRAILR3 Antibody, Rabbit Polyclonal

MBS8119397-01mL 0.1mL
EUR 300

Anti-DcR1/TRAILR3 Antibody, Rabbit Polyclonal

MBS8119397-5x01mL 5x0.1mL
EUR 1200

Anti-DcR1/TRAILR3 Antibody, Rabbit Polyclonal

MBS8119398-01mL 0.1mL
EUR 300

Anti-DcR1/TRAILR3 Antibody, Rabbit Polyclonal

MBS8119398-5x01mL 5x0.1mL
EUR 1200

TNFRSF6B/DCR3 Rabbit anti-Human Polyclonal Antibody

MBS2402673-005mL 0.05mL
EUR 615

TNFRSF6B/DCR3 Rabbit anti-Human Polyclonal Antibody

MBS2402673-5x005mL 5x0.05mL
EUR 2605

DcR2 (TNFRSF10D) rabbit polyclonal antibody, Purified

SP1174P 100 µg Ask for price

dcr-1 (Center) rabbit polyclonal antibody, Purified

AP11794PU-N 400 µl Ask for price

DcR3 (TNFRSF6B) rabbit polyclonal antibody, Aff - Purified

AP20562PU-N 100 µg Ask for price

DcR2 (TNFRSF10D) (Center) rabbit polyclonal antibody, Aff - Purified

AP54308PU-N 400 µl Ask for price

DcR3 (TNFRSF6B) (N-term) rabbit polyclonal antibody, Aff - Purified

AP54313PU-N 400 µl Ask for price

Rabbit anti-Caenorhabditis elegans dcr-1 Polyclonal Antibody

MBS7156397-INQUIRE INQUIRE Ask for price

DcR1 Rabbit pAb

E2252300 100ul
EUR 225
Description: Available in various conjugation types.

DCR1 Rabbit pAb

MBS8540897-01mL 0.1mL
EUR 305

DCR1 Rabbit pAb

MBS8540897-01mLAF405L 0.1mL(AF405L)
EUR 565

DCR1 Rabbit pAb

MBS8540897-01mLAF405S 0.1mL(AF405S)
EUR 565

DCR1 Rabbit pAb

MBS8540897-01mLAF610 0.1mL(AF610)
EUR 565

DCR1 Rabbit pAb

MBS8540897-01mLAF635 0.1mL(AF635)
EUR 565

Rabbit anti-Drosophila melanogaster (Fruit fly) Dcr-1 Polyclonal Antibody

MBS9014165-INQUIRE INQUIRE Ask for price

Rabbit anti-Shigella flexneri DCRB Polyclonal Antibody

MBS7163858-INQUIRE INQUIRE Ask for price

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508/S288c)(Baker's yeast) DCR2 Polyclonal Antibody

MBS9017504-INQUIRE INQUIRE Ask for price

Rabbit anti-Escherichia coli (strain K12) DCRB Polyclonal Antibody

MBS7166205-INQUIRE INQUIRE Ask for price

DcR1 / CD263 Rabbit mAb

57133 100ul
EUR 339

DcR1 / CD263 Rabbit mAb

A23554 100μL
EUR 83.2
Description: A synthetic peptide corresponding to a sequence within amino acids 158-257 of human MRPS15 (P82914).

DcR1/CD263 Rabbit mAb

E2R30207 100ul
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

DcR1/CD263 Rabbit mAb

A24912 200μL
EUR 88.56

DcR1/CD263 Rabbit mAb

A24993 50μL
EUR 226.72

Rabbit anti-Desulfovibrio vulgaris (strain Hildenborough/ATCC 29579/DSM 644/NCIMB 8303) DCRA Polyclonal Antibody

MBS7157242-INQUIRE INQUIRE Ask for price

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) DCR Polyclonal Antibody

MBS9009095-INQUIRE INQUIRE Ask for price

DcR1 Antibody

2179-002mg 0.02 mg
EUR 206.18
Description: DcR1 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts were expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.

DcR1 Antibody

2179-01mg 0.1 mg
EUR 523.7
Description: DcR1 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts were expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.

DcR1 Antibody

24079 100ul
EUR 479

DcR1 Antibody

24079-100ul 100ul
EUR 468

DcR1 Antibody

24113 100ul
EUR 479

DcR1 Antibody

24113-100ul 100ul
EUR 468

DcR1 Antibody

2299-002mg 0.02 mg
EUR 206.18
Description: DcR1 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.

DcR1 Antibody

2299-01mg 0.1 mg
EUR 523.7
Description: DcR1 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.

DcR1 Antibody

GWB-7FB943 0.5 ml Ask for price

DcR1 Antibody

MBS9412263-01mL 0.1mL
EUR 495

DcR1 Antibody

MBS9412263-5x01mL 5x0.1mL
EUR 2075

DcR1 Antibody

MBS9406958-01mL 0.1mL
EUR 495

DcR1 Antibody

MBS9406958-5x01mL 5x0.1mL
EUR 2075

DcR1 Antibody

MBS150747-01mg 0.1mg
EUR 445

DcR1 Antibody

MBS150747-5x01mg 5x0.1mg
EUR 1965

DcR1 Antibody

MBS150161-01mg 0.1mg
EUR 445

DcR1 Antibody

MBS150161-5x01mg 5x0.1mg
EUR 1965

DcR1 Antibody

C30584-100ul 100μl
EUR 217
Description: DcR1 Rabbit Polyclonal Antibody

DcR1 Antibody

C30584-50ul 50μl
EUR 143.5
Description: DcR1 Rabbit Polyclonal Antibody

Rabbit Polyclonal Antibody PC1 Rabbit Polyclonal Antibody

MBS9465163-005mL 0.05mL
EUR 300

Rabbit Polyclonal Antibody PC1 Rabbit Polyclonal Antibody

MBS9465163-01mL 0.1mL
EUR 390

Rabbit Polyclonal Antibody PC1 Rabbit Polyclonal Antibody

MBS9465163-5x01mL 5x0.1mL
EUR 1610

Rabbit Polyclonal Antibody PC4 Rabbit Polyclonal Antibody

MBS9465999-005mL 0.05mL
EUR 300

Rabbit Polyclonal Antibody PC4 Rabbit Polyclonal Antibody

MBS9465999-01mL 0.1mL
EUR 390

Rabbit Polyclonal Antibody PC4 Rabbit Polyclonal Antibody

MBS9465999-5x01mL 5x0.1mL
EUR 1610

Rabbit Polyclonal AntibodyPC1 Rabbit Polyclonal Antibody

53940 100ul
EUR 439

Rabbit Polyclonal AntibodyPC4 Rabbit Polyclonal Antibody

54946 100ul
EUR 439

Rabbit Polyclonal Anti-BAG4 rabbit polyclonal antibody

TA351743 100 µl Ask for price

Rabbit Polyclonal Anti-LPP rabbit polyclonal antibody

TA351364 100 µl Ask for price

Rabbit Polyclonal Anti-TPR rabbit polyclonal antibody

TA351467 100 µl Ask for price

DcR3 Polyclonal Antibody

ABP51153-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of DcR3 from Human. This DcR3 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human DcR3 at AA range: 220-300

DcR3 Polyclonal Antibody

ABP51153-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of DcR3 from Human. This DcR3 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human DcR3 at AA range: 220-300

DcR3 Polyclonal Antibody

ABP51153-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of DcR3 from Human. This DcR3 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human DcR3 at AA range: 220-300

DcR3 Polyclonal Antibody

E20-71303 100ug
EUR 225
Description: Available in various conjugation types.

DcR3 Polyclonal Antibody

E44H04497 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

DcR3 Polyclonal Antibody

BT-AP02525-100ul 100ul Ask for price
Description: TNFRSF6B belongs to the tumor necrosis factor receptor superfamily. TNF receptor superfamily member 6b is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript.

DcR3 Polyclonal Antibody

BT-AP02525-20ul 20ul Ask for price
Description: TNFRSF6B belongs to the tumor necrosis factor receptor superfamily. TNF receptor superfamily member 6b is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript.

DcR3 Polyclonal Antibody

BT-AP02525-50ul 50ul Ask for price
Description: TNFRSF6B belongs to the tumor necrosis factor receptor superfamily. TNF receptor superfamily member 6b is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript.

DcR3 Polyclonal Antibody

MBS9243379-01mL 0.1mL
EUR 415

DcR3 Polyclonal Antibody

MBS9243379-5x01mL 5x0.1mL
EUR 1841

DcR3 Polyclonal Antibody

MBS8522284-01mg 0.1mg
EUR 305

DcR3 Polyclonal Antibody

MBS8522284-01mLAF405L 0.1mL(AF405L)
EUR 465

DcR3 Polyclonal Antibody

MBS8522284-01mLAF405S 0.1mL(AF405S)
EUR 465

DcR3 Polyclonal Antibody

MBS8522284-01mLAF610 0.1mL(AF610)
EUR 465

DcR3 Polyclonal Antibody

MBS8522284-01mLAF635 0.1mL(AF635)
EUR 465

DcR3 Polyclonal Antibody

MBS2536043-002mL 0.02mL
EUR 140

DcR3 Polyclonal Antibody

MBS2536043-006mL 0.06mL
EUR 180

DcR3 Polyclonal Antibody

MBS2536043-012mL 0.12mL
EUR 260

DcR3 Polyclonal Antibody

MBS2536043-02mL 0.2mL
EUR 405

DcR3 Polyclonal Antibody

MBS2536043-5x02mL 5x0.2mL
EUR 1725

Rabbit Polyclonal Anti-RORA rabbit polyclonal antibody

TA351609 100 µl Ask for price

Rabbit Polyclonal Anti-SSX5 rabbit polyclonal antibody

TA351758 100 µl Ask for price

Rabbit Polyclonal Anti-TGM7 rabbit polyclonal antibody

TA351848 100 µl Ask for price

Rabbit Polyclonal Anti-NOX5 rabbit polyclonal antibody

TA350234 100 µl Ask for price

Rabbit Polyclonal Anti-SRPX rabbit polyclonal antibody

TA350419 100 µl Ask for price

Rabbit Polyclonal Anti-STX7 rabbit polyclonal antibody

TA350469 100 µl Ask for price

Rabbit Polyclonal Anti-STX8 rabbit polyclonal antibody

TA350470 100 µl Ask for price

Rabbit Polyclonal Anti-CERS3 rabbit polyclonal antibody

TA351342 100 µl Ask for price

Rabbit Polyclonal Anti-LLGL2 rabbit polyclonal antibody

TA351357 100 µl Ask for price

Rabbit Polyclonal Anti-PSMB8 rabbit polyclonal antibody

TA351358 100 µl Ask for price

Rabbit Polyclonal Anti-LONP1 rabbit polyclonal antibody

TA351359 100 µl Ask for price

Rabbit Polyclonal Anti-LOXL2 rabbit polyclonal antibody

TA351360 100 µl Ask for price

Rabbit Polyclonal Anti-LOXL3 rabbit polyclonal antibody

TA351362 100 µl Ask for price

Rabbit Polyclonal Anti-LOXL4 rabbit polyclonal antibody

TA351363 100 µl Ask for price

Rabbit Polyclonal Anti-LZTS1 rabbit polyclonal antibody

TA351367 100 µl Ask for price

Rabbit Polyclonal Anti-MACC1 rabbit polyclonal antibody

TA351368 100 µl Ask for price

Rabbit Polyclonal Anti-SMYD5 rabbit polyclonal antibody

TA351731 100 µl Ask for price

Rabbit Polyclonal Anti-TRPV5 rabbit polyclonal antibody

TA351861 100 µl Ask for price

Rabbit Polyclonal Anti-TRPV3 rabbit polyclonal antibody

TA351862 100 µl Ask for price

Rabbit Polyclonal Anti-SPARC rabbit polyclonal antibody

TA349441 100 µl Ask for price

Rabbit Polyclonal Anti-OLFM3 rabbit polyclonal antibody

TA350251 100 µl Ask for price

Rabbit Polyclonal Anti-OLFM4 rabbit polyclonal antibody

TA350252 100 µl Ask for price

Rabbit Polyclonal Anti-ROBO4 rabbit polyclonal antibody

TA350367 100 µl Ask for price

Rabbit Polyclonal Anti-RRAGA rabbit polyclonal antibody

TA350374 100 µl Ask for price

Rabbit Polyclonal Anti-SAMD7 rabbit polyclonal antibody

TA350388 100 µl Ask for price

Rabbit Polyclonal Anti-SEPP1 rabbit polyclonal antibody

TA350395 100 µl Ask for price

Rabbit Polyclonal Anti-SENP8 rabbit polyclonal antibody

TA350399 100 µl Ask for price

Rabbit Polyclonal Anti-SENP5 rabbit polyclonal antibody

TA350400 100 µl Ask for price

Rabbit Polyclonal Anti-SMYD3 rabbit polyclonal antibody

TA350428 100 µl Ask for price

Rabbit Polyclonal Anti-SMYD4 rabbit polyclonal antibody

TA350429 100 µl Ask for price

Rabbit Polyclonal Anti-SNAI3 rabbit polyclonal antibody

TA350430 100 µl Ask for price

Rabbit Polyclonal Anti-STX18 rabbit polyclonal antibody

TA350473 100 µl Ask for price

Rabbit Polyclonal Anti-STX11 rabbit polyclonal antibody

TA350476 100 µl Ask for price

Rabbit Polyclonal Anti-STX19 rabbit polyclonal antibody

TA350477 100 µl Ask for price

Rabbit Polyclonal Anti-TBX18 rabbit polyclonal antibody

TA350485 100 µl Ask for price

Rabbit Polyclonal Anti-TBX10 rabbit polyclonal antibody

TA350486 100 µl Ask for price

Rabbit Polyclonal Anti-EFNB3 rabbit polyclonal antibody

TA350660 100 µl Ask for price

Rabbit Polyclonal Anti-FOXG1 rabbit polyclonal antibody

TA350672 100 µl Ask for price

Rabbit Polyclonal Anti-LTB4R2 rabbit polyclonal antibody

TA351366 100 µl Ask for price

Rabbit Polyclonal Anti-AGPAT9 rabbit polyclonal antibody

TA351369 100 µl Ask for price

Rabbit Polyclonal Anti-MAGEB2 rabbit polyclonal antibody

TA351371 100 µl Ask for price

Rabbit Polyclonal Anti-SLC7A5 rabbit polyclonal antibody

TA351714 100 µl Ask for price

Rabbit Polyclonal Anti-AGPAT6 rabbit polyclonal antibody

TA351863 100 µl Ask for price

Rabbit Polyclonal Anti-PRSS50 rabbit polyclonal antibody

TA351865 100 µl Ask for price

Rabbit Polyclonal Anti-PTPMT1 rabbit polyclonal antibody

TA350308 100 µl Ask for price

Rabbit Polyclonal Anti-DHCR24 rabbit polyclonal antibody

TA350394 100 µl Ask for price

Rabbit Polyclonal Anti-SEMA4A rabbit polyclonal antibody

TA350396 100 µl Ask for price

Rabbit Polyclonal Anti-TRIM21 rabbit polyclonal antibody

TA350447 100 µl Ask for price

Rabbit Polyclonal Anti-STXBP4 rabbit polyclonal antibody

TA350474 100 µl Ask for price

Rabbit Polyclonal Anti-MAGEA11 rabbit polyclonal antibody

TA351370 100 µl Ask for price

Rabbit Polyclonal Anti-SLC16A9 rabbit polyclonal antibody

TA351677 100 µl Ask for price

Rabbit Polyclonal Anti-SLC24A6 rabbit polyclonal antibody

TA351684 100 µl Ask for price

Rabbit Polyclonal Anti-SLC17A1 rabbit polyclonal antibody

TA351718 100 µl Ask for price

Rabbit Polyclonal Anti-S100A14 rabbit polyclonal antibody

TA350383 100 µl Ask for price

Rabbit Polyclonal Anti-SH3KBP1 rabbit polyclonal antibody

TA350412 100 µl Ask for price

Human DcR1 Antibody

33476-05111 150 ug
EUR 215

Rabbit Polyclonal Anti-SERPINB1 rabbit polyclonal antibody

TA350405 100 µl Ask for price

Rabbit Polyclonal Anti-SERPINB6 rabbit polyclonal antibody

TA350406 100 µl Ask for price

Rabbit Polyclonal Anti-SERPINB8 rabbit polyclonal antibody

TA350407 100 µl Ask for price

Rabbit Polyclonal Anti-SIGLEC12 rabbit polyclonal antibody

TA350415 100 µl Ask for price

Rabbit Polyclonal Anti-SLC25A26 rabbit polyclonal antibody

TA350422 100 µl Ask for price

Polyclonal AntibodyP1 Rabbit Polyclonal Antibody

ES11752-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against P1. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP1 Rabbit Polyclonal Antibody

ES11752-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against P1. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP5 Rabbit Polyclonal Antibody

ES4829-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against P5 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Polyclonal AntibodyP5 Rabbit Polyclonal Antibody

ES4829-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against P5 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Polyclonal AntibodyP2 Rabbit Polyclonal Antibody

ES10016-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against P2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP2 Rabbit Polyclonal Antibody

ES10016-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against P2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP4 Rabbit Polyclonal Antibody

ES10017-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against P4 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP4 Rabbit Polyclonal Antibody

ES10017-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against P4 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

To our knowledge, this is the first report describing the implementation of high-resolution LC / MS method in commercial QC laboratories for product release and stability testing in the biopharmaceutical industry. This work paves the way for implementing additional LC / MS method to modernize commercial QC testing with targeted control over product quality.

Evelyn

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