ExoFACS kits ensure exosome isolation and exosome marker characterization via FACS, comprehensive exosome profiling, easy to use and suitable for multi-marker analysis, no initial exosome
Impact of enzymatic reduction on bivalent bispecific antibody fragmentation and loss of product purity upon reoxidation.
Antibody disulfide bond (DSB) reduction during the manufacturing process is a widely observed phenomenon is associated with the host cell reductase is present in the liquid cell culture harvest.
Improved host cell protein analysis in monoclonal antibody products through molecular weight cutoff enrichment.
host cell protein (HCP) which is related to the process of manure produced by the host organism and is typically present at low levels in recombinant biopharmaceutical products, such as therapeutic
Online coupling of analytical hydrophobic interaction chromatography with native mass spectrometry for the characterization of monoclonal antibodies and related products.
The original mass spectrometry (MS native) has seen a remarkable development and improvement of applications over the last decade to the study of proteins and protein complexes. Although
Impacts on Product Quality Attributes of Monoclonal Antibodies Produced in CHO Cell Bioreactor Cultures During Intentional Mycoplasma Contamination Events
A Mycoplasma contamination events in biomanufacturing facility can result in costly cleanup and potential drug shortages. Mycoplasma can survive in mammalian cell culture, with only subtle changes to
Exploring sample preparation and data evaluation strategies for enhanced identification of host cell proteins in drug products of therapeutic antibodies and Fc-fusion proteins
Biopharmaceutical manufacturing involves the expression of recombinant proteins in host cells followed by extensive purification of target proteins. However, the host cell protein (HCP) can survive
Production tools Each stage involving the use of mAb , from research to industrial production, involves significantly different quantities and quality of antibodies. The requirements