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Improved host cell protein analysis in monoclonal antibody products through molecular weight cutoff enrichment.

Improved host cell protein analysis in monoclonal antibody products through molecular weight cutoff enrichment.

host cell protein (HCP) which is related to the process of manure produced by the host organism and is typically present at low levels in recombinant biopharmaceutical products, such as therapeutic antibodies. While the overall level of HCP is usually monitored by enzyme-linked immunosorbent assay (ELISA), liquid chromatography coupled with mass spectrometry (LC-MS) is emerging as a powerful tool that can provide both qualitative and quantitative information about the level of HCP during the purification process development. However, a big challenge for LC-MS-based method is that there can be more than 5 orders of magnitude difference in concentrations between HCP and therapeutic antibodies in solution, which hinders effective identification of low abundance HCP in the product antibodies.

This work reports a simple and powerful strategy to identify HCP in antibody drug substance by implementing measures molecular weight cut-off (MWCO) filtration followed by shotgun proteomics analysis. After separating the interaction between HCPs and antibodies with anionic detergent, antibody depletion of HCP can be easily achieved with MWCO filtration step. By using this method, we observed that the dynamic range in the protein in the sample HCP significantly decreased to 1,000-fold. In addition, by spiking known amounts of HCP to purified antibody drug substance with low levels of HCP, we show that our method can detect HCP are low molecular weight (11 kDa and 17 kDa) at concentrations as low as 1 ppm.

When applying this methodology to study at NIST HCP monoclonal antibodies (NISTmAb), more than 150 HCPs who confidently identified, which doubles the amount of HCP identified previously reported. Parallel reaction monitoring (PRM) results confirms that the new HCP is found using this method are present in very low abundance (0.01 to 8 ppm), highlighting that our method reduces the dynamic range by removing the antibody interference and increases sensitivity HCP identification and quantification.

Improved host cell protein analysis in monoclonal antibody products through molecular weight cutoff enrichment.
Improved host cell protein analysis in monoclonal antibody products through molecular weight cutoff enrichment.

Sewing strength translations Kozak sequence variants increase bispecific antibody assembly and reducing impurities associated with the product in CHO cells.

The optimal production bispecific antibody requires an efficient and customized co-expression and assembly of two different heavy and two light chains are different. Here, we describe a new technology to modulate translational strength chain antibody through a Kozak sequence variants to generate bispecific antibodies in a single cell line. In this study, we designed and screened a large Kozak sequence library to identify 10 variants that can independently modulate protein expression levels of about 0.2 to 1.3-fold compared with the sequence of Wild-type transient transfection.

We use a combination of several variants, covering a range of translational strengths, to develop a single cell CHO cell lines bispecific stable and compared the results with those obtained from wild sequence types. A significant increase in the assembly of bispecific antibody with a concomitant reduction in the level of product-related impurities were observed.

Rabbit Polyclonal PLEKHM1 Antibody
TA306873 100 µg Ask for price

Rabbit Polyclonal PLEKHM3 Antibody
TA306875 100 µg Ask for price

PLEKHM1 (N-term) Rabbit Polyclonal Antibody
E10G31210 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHM3 (C-term) rabbit polyclonal antibody, Purified
AP23917PU-N 50 µg Ask for price

PLEKHM1 (N-term) rabbit polyclonal antibody, Aff - Purified
AP53352PU-N 400 µl Ask for price

PLEKHM2 Antibody
5485-002mg 0.02 mg
EUR 206.18
Description: PLEKHM2 Antibody: PLEKHM2, also known as SKIP, is a member of the M family of Pleckstrin homology domain-containing proteins. While little is known of PLEKHM2, a recent study examining differential gene expression in human hematopoietic stem cells has shown it to be specifically expressed in stem cells, suggesting that PLEKHM2 may play a role in erythroid commitment and development. Other studies have shown that PLEKHM2 is required for interaction with the Salmonella virulence factor SifA for Salmonella pathogenesis, suggesting that PLEKHM2 has cellular roles other than in the developing embryo.

PLEKHM2 Antibody
5485-01mg 0.1 mg
EUR 523.7
Description: PLEKHM2 Antibody: PLEKHM2, also known as SKIP, is a member of the M family of Pleckstrin homology domain-containing proteins. While little is known of PLEKHM2, a recent study examining differential gene expression in human hematopoietic stem cells has shown it to be specifically expressed in stem cells, suggesting that PLEKHM2 may play a role in erythroid commitment and development. Other studies have shown that PLEKHM2 is required for interaction with the Salmonella virulence factor SifA for Salmonella pathogenesis, suggesting that PLEKHM2 has cellular roles other than in the developing embryo.

PLEKHM2 Antibody
25004-100ul 100ul
EUR 468

PLEKHM2 Antibody
DF16018 100ul
EUR 420

PLEKHM2 Antibody
DF16018-100ul 100ul
EUR 168
Description: IHC,ELISA(peptide)

PLEKHM2 Antibody
DF16018-200ul 200ul
EUR 210
Description: IHC,ELISA(peptide)

PLEKHM2 Antibody
MBS150207-01mg 0.1mg
EUR 445

PLEKHM2 Antibody
MBS150207-5x01mg 5x0.1mg
EUR 1965

PLEKHM2 Antibody
MBS9631306-01mL 0.1mL
EUR 260

PLEKHM2 Antibody
MBS9631306-02mL 0.2mL
EUR 305

PLEKHM2 Antibody
MBS9631306-5x02mL 5x0.2mL
EUR 1220

PLEKHM2 Antibody
MBS9633689-1mg 1mg
EUR 375

PLEKHM2 Antibody
MBS9633689-5x1mg 5x1mg
EUR 1545

PLEKHM2 Antibody
MBS9402651-01mL 0.1mL
EUR 495

PLEKHM2 Antibody
MBS9402651-5x01mL 5x0.1mL
EUR 2075

PLEKHM3 Polyclonal Antibody
MBS9238427-01mL 0.1mL
EUR 415

PLEKHM3 Polyclonal Antibody
MBS9238427-5x01mL 5x0.1mL
EUR 1841

Polyclonal PLEKHM1 Antibody
APR12894G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PLEKHM1 . This antibody is tested and proven to work in the following applications:

Polyclonal PLEKHM3 Antibody
APR06585G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PLEKHM3 . This antibody is tested and proven to work in the following applications:

OAPB00994-100UG - PLEKHM2 Antibody
OAPB00994-100UG 0.1mg
EUR 389

Polyclonal PLEKHM1 Antibody (N-term)
APR12896G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PLEKHM1 (N-term). This antibody is tested and proven to work in the following applications:

Polyclonal PLEKHM3 Antibody (C-Terminus)
APR02719G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PLEKHM3 (C-Terminus). This antibody is tested and proven to work in the following applications:

PLEKHM2 Antibody - N-terminal region
MBS3220022-01mL 0.1mL
EUR 455

PLEKHM2 Antibody - N-terminal region
MBS3220022-5x01mL 5x0.1mL
EUR 1995

PLEKHA7 Rabbit Polyclonal Antibody
54563 100ul
EUR 439

PLEKHO1 Rabbit Polyclonal Antibody
E10G08162 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHG6 Rabbit Polyclonal Antibody
E10G08536 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHO1 Rabbit Polyclonal Antibody
E10G01216 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHG6 Rabbit Polyclonal Antibody
E10G01567 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHA1 Rabbit Polyclonal Antibody
E10G02706 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHF2 Rabbit Polyclonal Antibody
E10G03334 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHJ1 Rabbit Polyclonal Antibody
E10G03455 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHO1 Rabbit Polyclonal Antibody
E10G03823 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHA1 Rabbit Polyclonal Antibody
E10G09704 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHF2 Rabbit Polyclonal Antibody
E10G10330 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHJ1 Rabbit Polyclonal Antibody
E10G10458 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHA8 Rabbit Polyclonal Antibody
E10G31959 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHH1 Rabbit Polyclonal Antibody
E10G31158 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHA7 Rabbit Polyclonal Antibody
MBS9465698-005mL 0.05mL
EUR 300

PLEKHA7 Rabbit Polyclonal Antibody
MBS9465698-01mL 0.1mL
EUR 390

PLEKHA7 Rabbit Polyclonal Antibody
MBS9465698-5x01mL 5x0.1mL
EUR 1610

PLEKHM2 Peptide
5485P 0.05 mg
EUR 197.7
Description: (CT) PLEKHM2 peptide

PLEKHM2 Peptide
MBS153224-005mg 0.05mg
EUR 175

PLEKHM2 Peptide
MBS153224-5x005mg 5x0.05mg
EUR 770

PLEKHG5 rabbit polyclonal antibody, Serum
AP55132SU-N 200 µl Ask for price

ARP75458_P050-25UL - PLEKHM2 Antibody - N-terminal region
ARP75458_P050-25UL 25ul
EUR 99

PLEKHO1 (N-term) rabbit polyclonal antibody
AP17214PU-N 400 µl Ask for price

PLEKHF1 (N-term) Rabbit Polyclonal Antibody
E10G33764 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHA4 (N-term) Rabbit Polyclonal Antibody
E10G30998 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Mouse PLEKHM2 siRNA
20-abx928929
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

Human PLEKHM2 siRNA
20-abx928930
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

PLEKHM2 siRNA (Mouse)
MBS8218588-15nmol 15nmol
EUR 405

PLEKHM2 siRNA (Mouse)
MBS8218588-30nmol 30nmol
EUR 565

PLEKHM2 siRNA (Mouse)
MBS8218588-5x30nmol 5x30nmol
EUR 2450

PLEKHM2 siRNA (Human)
MBS8208485-15nmol 15nmol
EUR 405

PLEKHM2 siRNA (Human)
MBS8208485-30nmol 30nmol
EUR 565

PLEKHM2 siRNA (Human)
MBS8208485-5x30nmol 5x30nmol
EUR 2450

MyoGEF (PLEKHG6) (N-term) rabbit polyclonal antibody
AP17576PU-N 400 µl Ask for price

PLEKHO1 (C-term) rabbit polyclonal antibody, Purified
AP23907PU-N 50 µg Ask for price

PLEKHF2 (Center) rabbit polyclonal antibody, Aff - Purified
AP53349PU-N 400 µl Ask for price

PLEKHG1 (C-term) rabbit polyclonal antibody, Aff - Purified
AP53316PU-N 400 µl Ask for price

PLEKHH2 (C-term) rabbit polyclonal antibody, Aff - Purified
AP53317PU-N 400 µl Ask for price

PLEKHA4 (N-term) rabbit polyclonal antibody, Aff - Purified
AP53347PU-N 400 µl Ask for price

PLEKHG3 (C-term) rabbit polyclonal antibody, Aff - Purified
AP53350PU-N 400 µl Ask for price

PLEKHH1 (C-term) rabbit polyclonal antibody, Aff - Purified
AP53351PU-N 400 µl Ask for price

PLEKHO2 (N-term) rabbit polyclonal antibody, Aff - Purified
AP53353PU-N 400 µl Ask for price

Mouse Plekhm2 ELISA KIT
ELI-16361m 96 Tests
EUR 1038

Human PLEKHM2 ELISA KIT
ELI-45359h 96 Tests
EUR 988.8

Human PLEKHM2 shRNA Plasmid
20-abx958085
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

Mouse PLEKHM2 shRNA Plasmid
20-abx976983
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

Human PLEKHM2 Protein Lysate
MBS8417365-002mg 0.02mg
EUR 545

Human PLEKHM2 Protein Lysate
MBS8417365-5x002mg 5x0.02mg
EUR 2225

APPD (PLEKHF1) (N-term) rabbit polyclonal antibody, Aff - Purified
AP53348PU-N 400 µl Ask for price

PLEKHM2 (NM_015164) Human Recombinant Protein
E45H34733M5 20 ug
EUR 785.42

Plekhm2 (NM_001033150) Mouse Recombinant Protein
E45M44255M5 20 ug
EUR 1924.54

PLEKHM2 (NM_015164) Human Recombinant Protein
PROTQ8IWE5 20ug
EUR 1249
Description: Recombinant protein of human pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2)

PLEK2 Rabbit Polyclonal Antibody
BT-AP11999-100ul 100ul Ask for price
Description: The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1| q subcomponent| B chain (C1QB)| this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease.

PLEK2 Rabbit Polyclonal Antibody
BT-AP11999-20ul 20ul Ask for price
Description: The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1| q subcomponent| B chain (C1QB)| this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease.

PLEK2 Rabbit Polyclonal Antibody
BT-AP11999-50ul 50ul Ask for price
Description: The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1| q subcomponent| B chain (C1QB)| this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease.

PLEK2 Rabbit Polyclonal Antibody
JOT-AP11999-100ul 100ul
EUR 220

PLEK2 Rabbit Polyclonal Antibody
JOT-AP11999-50ul 50ul
EUR 144

Recombinant Human PLEKHM2 Protein
E30P64729A 50 ug
EUR 295

Rabbit anti-Mus musculus (Mouse) Plekha7 Polyclonal Antibody
MBS7193984-INQUIRE INQUIRE Ask for price

Plekhm2 ORF Vector (Rat) (pORF)
ORF073664 1.0 ug DNA
EUR 607.2

PLEKHM2 ORF Vector (Human) (pORF)
ORF027966 1.0 ug DNA
EUR 486

Plekhm2 ORF Vector (Mouse) (pORF)
ORF054293 1.0 ug DNA
EUR 607.2

PLEK Rabbit Polyclonal Antibody
54988 100ul
EUR 439

PLEK Rabbit Polyclonal Antibody
53565 100ul
EUR 439

PLEK Rabbit Polyclonal Antibody
BT-AP11997-100ul 100ul Ask for price

PLEK Rabbit Polyclonal Antibody
BT-AP11997-20ul 20ul Ask for price

PLEK Rabbit Polyclonal Antibody
BT-AP11997-50ul 50ul Ask for price

PLEK Rabbit Polyclonal Antibody
JOT-AP11997-100ul 100ul
EUR 220

PLEK Rabbit Polyclonal Antibody
JOT-AP11997-50ul 50ul
EUR 144

PLEK Rabbit Polyclonal Antibody
MBS9466040-005mL 0.05mL
EUR 300

PLEK Rabbit Polyclonal Antibody
MBS9466040-01mL 0.1mL
EUR 390

PLEK Rabbit Polyclonal Antibody
MBS9466040-5x01mL 5x0.1mL
EUR 1610

PLEK Rabbit Polyclonal Antibody
MBS9464819-005mL 0.05mL
EUR 300

PLEK Rabbit Polyclonal Antibody
MBS9464819-01mL 0.1mL
EUR 390

PLEK Rabbit Polyclonal Antibody
MBS9464819-5x01mL 5x0.1mL
EUR 1610

Human PLEKHM2 knockout cell line
ABC-KH11755 1 vial Ask for price
Description: Human PLEKHM2 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

PLEKHM2 (NM_015164) Human Over-expression Lysate
E45H09518-2 each
EUR 395

PLEKHM2 (NM_015164) Human Over-expression Lysate
LS023207 100ug
EUR 960
Description: Transient overexpression lysate of pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2)

Human PLEKHM2 knockdown cell line
ABC-KD11755 1 vial Ask for price
Description: Human PLEKHM2 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human PLEKHM2 Protein Lysate 20ug
IHUPLEKHM2PLLY20UG each
EUR 361
Description: Human PLEKHM2 Protein Lysate 20ug

PLEKHM2 Peptide - N-terminal region
MBS3244864-01mg 0.1mg
EUR 180

PLEKHM2 Peptide - N-terminal region
MBS3244864-5x01mg 5x0.1mg
EUR 730

OCOA10791-20UG - PLEKHM2 Protein Lysate
OCOA10791-20UG 20ug
EUR 269

Plekhm2 (untagged) - Rat pleckstrin homology domain containing, family M (with RUN domain) member 2 (Plekhm2)
RN217426 10 µg Ask for price

PLEKHM2 (untagged)-Human pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2)
SC316442 10 µg Ask for price

Plekhm2 (untagged) - Mouse pleckstrin homology domain containing, family M (with RUN domain) member 2 (Plekhm2), (10ug)
MC223279 10 µg Ask for price

PLEKHM2 (GFP-tagged) - Human pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2)
RG220299 10 µg Ask for price

Plekhm2 sgRNA CRISPR Lentivector set (Rat)
K6209501 3 x 1.0 ug
EUR 406.8

PLEKHM2 3'UTR GFP Stable Cell Line
TU068262 1.0 ml
EUR 2799.6

Plekhm2 3'UTR GFP Stable Cell Line
TU266407 1.0 ml Ask for price

Plekhm2 3'UTR GFP Stable Cell Line
TU166547 1.0 ml Ask for price

PLEKHM2 sgRNA CRISPR Lentivector set (Human)
K1668101 3 x 1.0 ug
EUR 406.8

Plekhm2 sgRNA CRISPR Lentivector set (Mouse)
K3493501 3 x 1.0 ug
EUR 406.8

Plekhm2 (GFP-tagged) - Mouse pleckstrin homology domain containing family M (with RUN domain) member 2 (Plekhm2), (10ug)
MG216370 10 µg Ask for price

Plekhm2 (myc-DDK-tagged) - Rat pleckstrin homology domain containing, family M (with RUN domain) member 2 (Plekhm2)
RR217426 10 µg Ask for price

Rabbit polyclonal antibody to PLEK (pleckstrin)
TA308338 100 µl Ask for price

PLEKHM2 Protein Vector (Rat) (pPM-C-HA)
PV294656 500 ng
EUR 1399.2

Plekhm2 (Myc-DDK-tagged) - Mouse pleckstrin homology domain containing, family M (with RUN domain) member 2 (Plekhm2)
MR216370 10 µg Ask for price

PLEKHM2 (Myc-DDK-tagged)-Human pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2)
RC220299 10 µg Ask for price

PLEKHM2 Protein Vector (Rat) (pPB-C-His)
PV294654 500 ng
EUR 1399.2

PLEKHM2 Protein Vector (Rat) (pPB-N-His)
PV294655 500 ng
EUR 1399.2

PLEKHM2 Protein Vector (Rat) (pPM-C-His)
PV294657 500 ng
EUR 1399.2

Rabbit anti-Danio rerio (Zebrafish)(Brachydanio rerio) plekha7 Polyclonal Antibody
MBS7141208-INQUIRE INQUIRE Ask for price

Rabbit anti-Danio rerio (Zebrafish)(Brachydanio rerio) plekhh1 Polyclonal Antibody
MBS7141209-INQUIRE INQUIRE Ask for price

Rabbit anti-Danio rerio (Zebrafish)(Brachydanio rerio) plekha8 Polyclonal Antibody
MBS7196309-INQUIRE INQUIRE Ask for price

Rabbit anti-Danio rerio (Zebrafish)(Brachydanio rerio) plekhj1 Polyclonal Antibody
MBS7197597-INQUIRE INQUIRE Ask for price

Rabbit anti-Danio rerio (Zebrafish)(Brachydanio rerio) plekho1a Polyclonal Antibody
MBS7168014-INQUIRE INQUIRE Ask for price

Rabbit anti-Danio rerio (Zebrafish)(Brachydanio rerio) plekhf2 Polyclonal Antibody
MBS9000198-INQUIRE INQUIRE Ask for price

PLEKHM2 Protein Vector (Human) (pPM-C-HA)
PV111864 500 ng
EUR 973.2

PLEKHM2 Protein Vector (Mouse) (pPM-C-HA)
PV217172 500 ng
EUR 1278

PLEKHM2 Protein Vector (Human) (pPB-C-His)
PV111862 500 ng
EUR 973.2

PLEKHM2 Protein Vector (Human) (pPB-N-His)
PV111863 500 ng
EUR 973.2

PLEKHM2 Protein Vector (Human) (pPM-C-His)
PV111865 500 ng
EUR 973.2

PLEKHM2 Protein Vector (Mouse) (pPB-C-His)
PV217170 500 ng
EUR 1278

PLEKHM2 Protein Vector (Mouse) (pPB-N-His)
PV217171 500 ng
EUR 1278

PLEKHM2 Protein Vector (Mouse) (pPM-C-His)
PV217173 500 ng
EUR 1278

PLEKHM2 3'UTR Luciferase Stable Cell Line
TU018262 1.0 ml
EUR 2799.6

Plekhm2 3'UTR Luciferase Stable Cell Line
TU116547 1.0 ml Ask for price

Plekhm2 3'UTR Luciferase Stable Cell Line
TU216407 1.0 ml Ask for price

PLEKHM2 (untagged)-Homo sapiens, clone IMAGE:3507149
SC106144 10 µg Ask for price

Plekhm2 sgRNA CRISPR Lentivector (Rat) (Target 1)
K6209502 1.0 ug DNA
EUR 184.8

Plekhm2 sgRNA CRISPR Lentivector (Rat) (Target 2)
K6209503 1.0 ug DNA
EUR 184.8

Plekhm2 sgRNA CRISPR Lentivector (Rat) (Target 3)
K6209504 1.0 ug DNA
EUR 184.8

PLEKHM2 sgRNA CRISPR Lentivector (Human) (Target 1)
K1668102 1.0 ug DNA
EUR 184.8

PLEKHM2 sgRNA CRISPR Lentivector (Human) (Target 2)
K1668103 1.0 ug DNA
EUR 184.8

PLEKHM2 sgRNA CRISPR Lentivector (Human) (Target 3)
K1668104 1.0 ug DNA
EUR 184.8

Plekhm2 sgRNA CRISPR Lentivector (Mouse) (Target 1)
K3493502 1.0 ug DNA
EUR 184.8

Plekhm2 sgRNA CRISPR Lentivector (Mouse) (Target 2)
K3493503 1.0 ug DNA
EUR 184.8

Plekhm2 sgRNA CRISPR Lentivector (Mouse) (Target 3)
K3493504 1.0 ug DNA
EUR 184.8

Lenti ORF particles, PLEKHM2 (mGFP-tagged) - Human pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2), 200ul, >
RC220299L4V 200 µl Ask for price

Lenti ORF particles, Plekhm2 (GFP-tagged) - Mouse pleckstrin homology domain containing, family M (with RUN domain) member 2 (Plekhm2), 200ul, >1
MR216370L4V 200 µl Ask for price

Lenti ORF particles, PLEKHM2 (Myc-DDK tagged) - Human pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2), 200ul
RC220299L3V 200 µl Ask for price

PLEKHM1 (N-term) Rabbit pAb
E2612198 100ul
EUR 225
Description: Available in various conjugation types.

PLEKHM1 (N-Term) Rabbit pAb
MBS8551894-01mL 0.1mL
EUR 305

PLEKHM1 (N-Term) Rabbit pAb
MBS8551894-01mLAF405L 0.1mL(AF405L)
EUR 565

PLEKHM1 (N-Term) Rabbit pAb
MBS8551894-01mLAF405S 0.1mL(AF405S)
EUR 565

PLEKHM1 (N-Term) Rabbit pAb
MBS8551894-01mLAF610 0.1mL(AF610)
EUR 565

PLEKHM1 (N-Term) Rabbit pAb
MBS8551894-01mLAF635 0.1mL(AF635)
EUR 565

Lenti ORF clone of Plekhm2 (mGFP-tagged) - Mouse pleckstrin homology domain containing, family M (with RUN domain) member 2 (Plekhm2)
MR216370L4 10 µg Ask for price

Lenti ORF particles, Plekhm2 (Myc-DDK-tagged) - Mouse pleckstrin homology domain containing, family M (with RUN domain) member 2 (Plekhm2), 200ul
MR216370L3V 200 µl Ask for price

Lenti ORF clone of Plekhm2 (Myc-DDK-tagged) - Mouse pleckstrin homology domain containing, family M (with RUN domain) member 2 (Plekhm2)
MR216370L3 10 µg Ask for price

Recombinant Mouse PLEKHM2 Protein, His (Fc)-Avi-tagged
PLEKHM2-6842M 50ug
EUR 2398.4
Description: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.

Rabbit polyclonal antibody to PLEKHG4 (pleckstrin homology domain containing, family G (with RhoGef domain) member 4)
TA308094 100 µl Ask for price

Rabbit Polyclonal to Human PLEKHO1 / CKIP-1
MBS244031-005mg 0.05mg
EUR 715

Rabbit Polyclonal to Human PLEKHO1 / CKIP-1
MBS244031-5x005mg 5x0.05mg
EUR 3035

Rabbit Polyclonal Antibody PC4 Rabbit Polyclonal Antibody
MBS9465999-005mL 0.05mL
EUR 300

Rabbit Polyclonal Antibody PC4 Rabbit Polyclonal Antibody
MBS9465999-01mL 0.1mL
EUR 390

Rabbit Polyclonal Antibody PC4 Rabbit Polyclonal Antibody
MBS9465999-5x01mL 5x0.1mL
EUR 1610

Rabbit Polyclonal Antibody PC1 Rabbit Polyclonal Antibody
MBS9465163-005mL 0.05mL
EUR 300

Rabbit Polyclonal Antibody PC1 Rabbit Polyclonal Antibody
MBS9465163-01mL 0.1mL
EUR 390

Rabbit Polyclonal Antibody PC1 Rabbit Polyclonal Antibody
MBS9465163-5x01mL 5x0.1mL
EUR 1610

Rabbit Polyclonal AntibodyPC4 Rabbit Polyclonal Antibody
54946 100ul
EUR 439

Rabbit Polyclonal AntibodyPC1 Rabbit Polyclonal Antibody
53940 100ul
EUR 439

PLEC Rabbit Polyclonal Antibody
E10G34436 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEC Rabbit Polyclonal Antibody
E10G12059 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEC Rabbit Polyclonal Antibody
ES10012-100ul 100ul
EUR 124
Description: IHC

PLEC Rabbit Polyclonal Antibody
ES10012-50ul 50ul
EUR 74
Description: IHC

PLEKHM2 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
SR308091 2 nmol Ask for price

Plekhm2 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each
SR421801 2 nmol Ask for price

Plekhm2 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)
K6209505 3 x 1.0 ug
EUR 451.2

PLEKHM2 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
K1668105 3 x 1.0 ug
EUR 451.2

Our findings suggest that for the production of bispecific antibodies that can be advantageous to modify the strength of translational for the selected protein chain in order to improve overall yield and product quality. By extension, tuning translational force can also be applied to improve the production of various heterologous proteins. This article is protected by copyright. All rights reserved.

Evelyn

Evelyn

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