Improved host cell protein analysis in monoclonal antibody products through molecular weight cutoff enrichment.

Improved host cell protein analysis in monoclonal antibody products through molecular weight cutoff enrichment.

host cell protein (HCP) which is related to the process of manure produced by the host organism and is typically present at low levels in recombinant biopharmaceutical products, such as therapeutic antibodies. While the overall level of HCP is usually monitored by enzyme-linked immunosorbent assay (ELISA), liquid chromatography coupled with mass spectrometry (LC-MS) is emerging as a powerful tool that can provide both qualitative and quantitative information about the level of HCP during the purification process development. However, a big challenge for LC-MS-based method is that there can be more than 5 orders of magnitude difference in concentrations between HCP and therapeutic antibodies in solution, which hinders effective identification of low abundance HCP in the product antibodies.

This work reports a simple and powerful strategy to identify HCP in antibody drug substance by implementing measures molecular weight cut-off (MWCO) filtration followed by shotgun proteomics analysis. After separating the interaction between HCPs and antibodies with anionic detergent, antibody depletion of HCP can be easily achieved with MWCO filtration step. By using this method, we observed that the dynamic range in the protein in the sample HCP significantly decreased to 1,000-fold. In addition, by spiking known amounts of HCP to purified antibody drug substance with low levels of HCP, we show that our method can detect HCP are low molecular weight (11 kDa and 17 kDa) at concentrations as low as 1 ppm.

When applying this methodology to study at NIST HCP monoclonal antibodies (NISTmAb), more than 150 HCPs who confidently identified, which doubles the amount of HCP identified previously reported. Parallel reaction monitoring (PRM) results confirms that the new HCP is found using this method are present in very low abundance (0.01 to 8 ppm), highlighting that our method reduces the dynamic range by removing the antibody interference and increases sensitivity HCP identification and quantification.

 Improved host cell protein analysis in monoclonal antibody products through molecular weight cutoff enrichment.
Improved host cell protein analysis in monoclonal antibody products through molecular weight cutoff enrichment.

Sewing strength translations Kozak sequence variants increase bispecific antibody assembly and reducing impurities associated with the product in CHO cells.

The optimal production bispecific antibody requires an efficient and customized co-expression and assembly of two different heavy and two light chains are different. Here, we describe a new technology to modulate translational strength chain antibody through a Kozak sequence variants to generate bispecific antibodies in a single cell line. In this study, we designed and screened a large Kozak sequence library to identify 10 variants that can independently modulate protein expression levels of about 0.2 to 1.3-fold compared with the sequence of Wild-type transient transfection.

We use a combination of several variants, covering a range of translational strengths, to develop a single cell CHO cell lines bispecific stable and compared the results with those obtained from wild sequence types. A significant increase in the assembly of bispecific antibody with a concomitant reduction in the level of product-related impurities were observed.

Rabbit Polyclonal PLEKHM3 Antibody

TA306875 100 µg Ask for price

Polyclonal PLEKHM2 / SKIP Antibody (C-Terminus)

APG02970G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PLEKHM2 / SKIP (C-Terminus). This antibody is tested and proven to work in the following applications:

PLEKHM1 (N-term) Rabbit Polyclonal Antibody

E10G31210 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHM3 (C-term) rabbit polyclonal antibody, Purified

AP23917PU-N 50 µg Ask for price

PLEKHM1 (N-term) rabbit polyclonal antibody, Aff - Purified

AP53352PU-N 400 µl Ask for price

PLEKHM2 Antibody

25004-100ul 100ul
EUR 468

PLEKHM2 Antibody

DF16018 100ul
EUR 420

PLEKHM2 Antibody

DF16018-100ul 100ul
EUR 280

PLEKHM2 Antibody

DF16018-200ul 200ul
EUR 350

PLEKHM2 Antibody

5485-002mg 0.02 mg
EUR 206.18
Description: PLEKHM2 Antibody: PLEKHM2, also known as SKIP, is a member of the M family of Pleckstrin homology domain-containing proteins. While little is known of PLEKHM2, a recent study examining differential gene expression in human hematopoietic stem cells has shown it to be specifically expressed in stem cells, suggesting that PLEKHM2 may play a role in erythroid commitment and development. Other studies have shown that PLEKHM2 is required for interaction with the Salmonella virulence factor SifA for Salmonella pathogenesis, suggesting that PLEKHM2 has cellular roles other than in the developing embryo.

PLEKHM2 Antibody

5485-01mg 0.1 mg
EUR 523.7
Description: PLEKHM2 Antibody: PLEKHM2, also known as SKIP, is a member of the M family of Pleckstrin homology domain-containing proteins. While little is known of PLEKHM2, a recent study examining differential gene expression in human hematopoietic stem cells has shown it to be specifically expressed in stem cells, suggesting that PLEKHM2 may play a role in erythroid commitment and development. Other studies have shown that PLEKHM2 is required for interaction with the Salmonella virulence factor SifA for Salmonella pathogenesis, suggesting that PLEKHM2 has cellular roles other than in the developing embryo.

Polyclonal PLEKHM1 Antibody

APR12894G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PLEKHM1 . This antibody is tested and proven to work in the following applications:

Polyclonal PLEKHM3 Antibody

APR06585G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PLEKHM3 . This antibody is tested and proven to work in the following applications:

Polyclonal PLEKHM1 Antibody (N-term)

APR12896G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PLEKHM1 (N-term). This antibody is tested and proven to work in the following applications:

Polyclonal PLEKHM3 Antibody (C-Terminus)

APR02719G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PLEKHM3 (C-Terminus). This antibody is tested and proven to work in the following applications:

PLEKHA7 Rabbit Polyclonal Antibody

54563 100ul
EUR 439

PLEKHH1 Rabbit Polyclonal Antibody

E10G31158 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHA8 Rabbit Polyclonal Antibody

E10G31959 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHO1 Rabbit Polyclonal Antibody

E10G08162 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHG6 Rabbit Polyclonal Antibody

E10G08536 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHA1 Rabbit Polyclonal Antibody

E10G09704 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHF2 Rabbit Polyclonal Antibody

E10G10330 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHJ1 Rabbit Polyclonal Antibody

E10G10458 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHO1 Rabbit Polyclonal Antibody

E10G03823 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHO1 Rabbit Polyclonal Antibody

E10G01216 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHG6 Rabbit Polyclonal Antibody

E10G01567 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHA1 Rabbit Polyclonal Antibody

E10G02706 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHF2 Rabbit Polyclonal Antibody

E10G03334 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHJ1 Rabbit Polyclonal Antibody

E10G03455 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

OAPB00994-100UG - PLEKHM2 Antibody

OAPB00994-100UG 0.1mg
EUR 389

PLEKHG5 rabbit polyclonal antibody, Serum

AP55132SU-N 200 µl Ask for price

PLEKHO1 (N-term) rabbit polyclonal antibody

AP17214PU-N 400 µl Ask for price

PLEKHA4 (N-term) Rabbit Polyclonal Antibody

E10G30998 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEKHF1 (N-term) Rabbit Polyclonal Antibody

E10G33764 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

MyoGEF (PLEKHG6) (N-term) rabbit polyclonal antibody

AP17576PU-N 400 µl Ask for price

PLEKHO1 (C-term) rabbit polyclonal antibody, Purified

AP23907PU-N 50 µg Ask for price

PLEKHF2 (Center) rabbit polyclonal antibody, Aff - Purified

AP53349PU-N 400 µl Ask for price

PLEKHG1 (C-term) rabbit polyclonal antibody, Aff - Purified

AP53316PU-N 400 µl Ask for price

PLEKHH2 (C-term) rabbit polyclonal antibody, Aff - Purified

AP53317PU-N 400 µl Ask for price

PLEKHA4 (N-term) rabbit polyclonal antibody, Aff - Purified

AP53347PU-N 400 µl Ask for price

PLEKHG3 (C-term) rabbit polyclonal antibody, Aff - Purified

AP53350PU-N 400 µl Ask for price

PLEKHH1 (C-term) rabbit polyclonal antibody, Aff - Purified

AP53351PU-N 400 µl Ask for price

PLEKHO2 (N-term) rabbit polyclonal antibody, Aff - Purified

AP53353PU-N 400 µl Ask for price

PLEKHM2 siRNA

20-abx928929
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

PLEKHM2 siRNA

20-abx928930
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

PLEKHM2 Peptide

5485P 0.05 mg
EUR 197.7
Description: (CT) PLEKHM2 peptide

APPD (PLEKHF1) (N-term) rabbit polyclonal antibody, Aff - Purified

AP53348PU-N 400 µl Ask for price

PLEK Rabbit Polyclonal Antibody

54988 100ul
EUR 439

PLEK Rabbit Polyclonal Antibody

53565 100ul
EUR 439

ARP75458_P050-25UL - PLEKHM2 Antibody - N-terminal region

ARP75458_P050-25UL 25ul
EUR 99

Rabbit polyclonal antibody to PLEK (pleckstrin)

TA308338 100 µl Ask for price

Human PLEKHM2 ELISA KIT

ELI-45359h 96 Tests
EUR 988.8

Mouse Plekhm2 ELISA KIT

ELI-16361m 96 Tests
EUR 1038

Human PLEKHM2 shRNA Plasmid

20-abx958085
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

Mouse PLEKHM2 shRNA Plasmid

20-abx976983
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

Plekhm2 ORF Vector (Rat) (pORF)

ORF073664 1.0 ug DNA
EUR 607.2

Rabbit Polyclonal AntibodyPC4 Rabbit Polyclonal Antibody

54946 100ul
EUR 439

Rabbit Polyclonal AntibodyPC1 Rabbit Polyclonal Antibody

53940 100ul
EUR 439

PLEKHM2 ORF Vector (Human) (pORF)

ORF027966 1.0 ug DNA
EUR 486

Plekhm2 ORF Vector (Mouse) (pORF)

ORF054293 1.0 ug DNA
EUR 607.2

Human PLEKHM2 knockout cell line

ABC-KH11755 1 vial Ask for price
Description: Human PLEKHM2 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human PLEKHM2 knockdown cell line

ABC-KD11755 1 vial Ask for price
Description: Human PLEKHM2 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human PLEKHM2 Protein Lysate 20ug

IHUPLEKHM2PLLY20UG each
EUR 361
Description: Human PLEKHM2 Protein Lysate 20ug

PLEC Rabbit Polyclonal Antibody

ES10012-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against PLEC from Human/Mouse/Rat. This antibody is tested and validated for IHC

PLEC Rabbit Polyclonal Antibody

ES10012-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against PLEC from Human/Mouse/Rat. This antibody is tested and validated for IHC

PLEC Rabbit Polyclonal Antibody

E10G34436 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PLEC Rabbit Polyclonal Antibody

E10G12059 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Rabbit Polyclonal Anti-BAG4 rabbit polyclonal antibody

TA351743 100 µl Ask for price

Rabbit Polyclonal Anti-LPP rabbit polyclonal antibody

TA351364 100 µl Ask for price

Rabbit Polyclonal Anti-TPR rabbit polyclonal antibody

TA351467 100 µl Ask for price

Rabbit Polyclonal Anti-RORA rabbit polyclonal antibody

TA351609 100 µl Ask for price

Rabbit Polyclonal Anti-SSX5 rabbit polyclonal antibody

TA351758 100 µl Ask for price

Rabbit Polyclonal Anti-TGM7 rabbit polyclonal antibody

TA351848 100 µl Ask for price

Rabbit Polyclonal Anti-SRPX rabbit polyclonal antibody

TA350419 100 µl Ask for price

Rabbit Polyclonal Anti-STX7 rabbit polyclonal antibody

TA350469 100 µl Ask for price

Rabbit Polyclonal Anti-STX8 rabbit polyclonal antibody

TA350470 100 µl Ask for price

Rabbit Polyclonal Anti-NOX5 rabbit polyclonal antibody

TA350234 100 µl Ask for price

Rabbit Polyclonal Anti-CERS3 rabbit polyclonal antibody

TA351342 100 µl Ask for price

Rabbit Polyclonal Anti-LLGL2 rabbit polyclonal antibody

TA351357 100 µl Ask for price

Rabbit Polyclonal Anti-PSMB8 rabbit polyclonal antibody

TA351358 100 µl Ask for price

Rabbit Polyclonal Anti-LONP1 rabbit polyclonal antibody

TA351359 100 µl Ask for price

Rabbit Polyclonal Anti-LOXL2 rabbit polyclonal antibody

TA351360 100 µl Ask for price

Rabbit Polyclonal Anti-LOXL3 rabbit polyclonal antibody

TA351362 100 µl Ask for price

Rabbit Polyclonal Anti-LOXL4 rabbit polyclonal antibody

TA351363 100 µl Ask for price

Rabbit Polyclonal Anti-LZTS1 rabbit polyclonal antibody

TA351367 100 µl Ask for price

Rabbit Polyclonal Anti-MACC1 rabbit polyclonal antibody

TA351368 100 µl Ask for price

Rabbit Polyclonal Anti-SMYD5 rabbit polyclonal antibody

TA351731 100 µl Ask for price

Rabbit Polyclonal Anti-TRPV5 rabbit polyclonal antibody

TA351861 100 µl Ask for price

Rabbit Polyclonal Anti-TRPV3 rabbit polyclonal antibody

TA351862 100 µl Ask for price

Rabbit Polyclonal Anti-ROBO4 rabbit polyclonal antibody

TA350367 100 µl Ask for price

Rabbit Polyclonal Anti-RRAGA rabbit polyclonal antibody

TA350374 100 µl Ask for price

Rabbit Polyclonal Anti-SAMD7 rabbit polyclonal antibody

TA350388 100 µl Ask for price

Rabbit Polyclonal Anti-SEPP1 rabbit polyclonal antibody

TA350395 100 µl Ask for price

Rabbit Polyclonal Anti-SENP8 rabbit polyclonal antibody

TA350399 100 µl Ask for price

Rabbit Polyclonal Anti-SENP5 rabbit polyclonal antibody

TA350400 100 µl Ask for price

Rabbit Polyclonal Anti-SMYD3 rabbit polyclonal antibody

TA350428 100 µl Ask for price

Rabbit Polyclonal Anti-SMYD4 rabbit polyclonal antibody

TA350429 100 µl Ask for price

Rabbit Polyclonal Anti-SNAI3 rabbit polyclonal antibody

TA350430 100 µl Ask for price

Rabbit Polyclonal Anti-STX18 rabbit polyclonal antibody

TA350473 100 µl Ask for price

Rabbit Polyclonal Anti-STX11 rabbit polyclonal antibody

TA350476 100 µl Ask for price

Rabbit Polyclonal Anti-STX19 rabbit polyclonal antibody

TA350477 100 µl Ask for price

Rabbit Polyclonal Anti-TBX18 rabbit polyclonal antibody

TA350485 100 µl Ask for price

Rabbit Polyclonal Anti-TBX10 rabbit polyclonal antibody

TA350486 100 µl Ask for price

Rabbit Polyclonal Anti-EFNB3 rabbit polyclonal antibody

TA350660 100 µl Ask for price

Rabbit Polyclonal Anti-FOXG1 rabbit polyclonal antibody

TA350672 100 µl Ask for price

Rabbit Polyclonal Anti-SPARC rabbit polyclonal antibody

TA349441 100 µl Ask for price

Rabbit Polyclonal Anti-OLFM3 rabbit polyclonal antibody

TA350251 100 µl Ask for price

Rabbit Polyclonal Anti-OLFM4 rabbit polyclonal antibody

TA350252 100 µl Ask for price

Rabbit Polyclonal Anti-LTB4R2 rabbit polyclonal antibody

TA351366 100 µl Ask for price

Rabbit Polyclonal Anti-AGPAT9 rabbit polyclonal antibody

TA351369 100 µl Ask for price

Rabbit Polyclonal Anti-MAGEB2 rabbit polyclonal antibody

TA351371 100 µl Ask for price

Rabbit Polyclonal Anti-SLC7A5 rabbit polyclonal antibody

TA351714 100 µl Ask for price

Rabbit Polyclonal Anti-AGPAT6 rabbit polyclonal antibody

TA351863 100 µl Ask for price

Rabbit Polyclonal Anti-PRSS50 rabbit polyclonal antibody

TA351865 100 µl Ask for price

Rabbit Polyclonal Anti-PTPMT1 rabbit polyclonal antibody

TA350308 100 µl Ask for price

Rabbit Polyclonal Anti-DHCR24 rabbit polyclonal antibody

TA350394 100 µl Ask for price

Rabbit Polyclonal Anti-SEMA4A rabbit polyclonal antibody

TA350396 100 µl Ask for price

Rabbit Polyclonal Anti-TRIM21 rabbit polyclonal antibody

TA350447 100 µl Ask for price

Rabbit Polyclonal Anti-STXBP4 rabbit polyclonal antibody

TA350474 100 µl Ask for price

OCOA10791-20UG - PLEKHM2 Protein Lysate

OCOA10791-20UG 20ug
EUR 269

Rabbit Polyclonal Anti-MAGEA11 rabbit polyclonal antibody

TA351370 100 µl Ask for price

Rabbit Polyclonal Anti-SLC16A9 rabbit polyclonal antibody

TA351677 100 µl Ask for price

Rabbit Polyclonal Anti-SLC24A6 rabbit polyclonal antibody

TA351684 100 µl Ask for price

Rabbit Polyclonal Anti-SLC17A1 rabbit polyclonal antibody

TA351718 100 µl Ask for price

Rabbit Polyclonal Anti-S100A14 rabbit polyclonal antibody

TA350383 100 µl Ask for price

Rabbit Polyclonal Anti-SH3KBP1 rabbit polyclonal antibody

TA350412 100 µl Ask for price

Rabbit Polyclonal Anti-SERPINB1 rabbit polyclonal antibody

TA350405 100 µl Ask for price

Rabbit Polyclonal Anti-SERPINB6 rabbit polyclonal antibody

TA350406 100 µl Ask for price

Rabbit Polyclonal Anti-SERPINB8 rabbit polyclonal antibody

TA350407 100 µl Ask for price

Rabbit Polyclonal Anti-SIGLEC12 rabbit polyclonal antibody

TA350415 100 µl Ask for price

Rabbit Polyclonal Anti-SLC25A26 rabbit polyclonal antibody

TA350422 100 µl Ask for price

Plekhm2 (untagged) - Rat pleckstrin homology domain containing, family M (with RUN domain) member 2 (Plekhm2)

RN217426 10 µg Ask for price

Polyclonal AntibodyP2 Rabbit Polyclonal Antibody

ES10016-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against P2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP2 Rabbit Polyclonal Antibody

ES10016-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against P2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP4 Rabbit Polyclonal Antibody

ES10017-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against P4 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP4 Rabbit Polyclonal Antibody

ES10017-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against P4 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP1 Rabbit Polyclonal Antibody

ES11752-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against P1. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP1 Rabbit Polyclonal Antibody

ES11752-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against P1. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP5 Rabbit Polyclonal Antibody

ES4829-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against P5 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Polyclonal AntibodyP5 Rabbit Polyclonal Antibody

ES4829-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against P5 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Polyclonal AntibodyP3 Rabbit Polyclonal Antibody

ES6454-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against P3 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Polyclonal AntibodyP3 Rabbit Polyclonal Antibody

ES6454-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against P3 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

PLEKHM2 (untagged)-Human pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2)

SC316442 10 µg Ask for price

PLEKHM2 3'UTR GFP Stable Cell Line

TU068262 1.0 ml
EUR 2799.6

Plekhm2 3'UTR GFP Stable Cell Line

TU266407 1.0 ml Ask for price

Plekhm2 3'UTR GFP Stable Cell Line

TU166547 1.0 ml Ask for price

Plekhm2 sgRNA CRISPR Lentivector set (Rat)

K6209501 3 x 1.0 ug
EUR 406.8

Rabbit polyclonal antibody to PLEKHG4 (pleckstrin homology domain containing, family G (with RhoGef domain) member 4)

TA308094 100 µl Ask for price

Plekhm2 (untagged) - Mouse pleckstrin homology domain containing, family M (with RUN domain) member 2 (Plekhm2), (10ug)

MC223279 10 µg Ask for price

PLEKHM2 (GFP-tagged) - Human pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2)

RG220299 10 µg Ask for price

ATM Rabbit Rabbit Polyclonal Antibody

ES8456-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against ATM Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATM Rabbit Rabbit Polyclonal Antibody

ES8456-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against ATM Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATM Rabbit Rabbit Polyclonal Antibody

ES8457-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against ATM Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATM Rabbit Rabbit Polyclonal Antibody

ES8457-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against ATM Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

VEGF Rabbit Rabbit Polyclonal Antibody

ES8453-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against VEGF Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

VEGF Rabbit Rabbit Polyclonal Antibody

ES8453-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against VEGF Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

CD10 Rabbit Rabbit Polyclonal Antibody

ES8454-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against CD10 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

CD10 Rabbit Rabbit Polyclonal Antibody

ES8454-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against CD10 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

JAK1 Rabbit Rabbit Polyclonal Antibody

ES8562-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against JAK1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

JAK1 Rabbit Rabbit Polyclonal Antibody

ES8562-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against JAK1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

JAK2 Rabbit Rabbit Polyclonal Antibody

ES8563-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against JAK2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

JAK2 Rabbit Rabbit Polyclonal Antibody

ES8563-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against JAK2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

JNK2 Rabbit Rabbit Polyclonal Antibody

ES8564-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against JNK2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

JNK2 Rabbit Rabbit Polyclonal Antibody

ES8564-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against JNK2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

JNK3 Rabbit Rabbit Polyclonal Antibody

ES8565-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against JNK3 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

JNK3 Rabbit Rabbit Polyclonal Antibody

ES8565-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against JNK3 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

MEK2 Rabbit Rabbit Polyclonal Antibody

ES8566-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against MEK2 Rabbit from Human. This antibody is tested and validated for WB, ELISA, IHC

MEK2 Rabbit Rabbit Polyclonal Antibody

ES8566-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against MEK2 Rabbit from Human. This antibody is tested and validated for WB, ELISA, IHC

MEK3 Rabbit Rabbit Polyclonal Antibody

ES8567-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against MEK3 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

MEK3 Rabbit Rabbit Polyclonal Antibody

ES8567-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against MEK3 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

Nrf2 Rabbit Rabbit Polyclonal Antibody

ES8568-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Nrf2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

Nrf2 Rabbit Rabbit Polyclonal Antibody

ES8568-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Nrf2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG5 Rabbit Rabbit Polyclonal Antibody

ES8572-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against ATG5 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG5 Rabbit Rabbit Polyclonal Antibody

ES8572-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against ATG5 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG7 Rabbit Rabbit Polyclonal Antibody

ES8573-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against ATG7 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG7 Rabbit Rabbit Polyclonal Antibody

ES8573-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against ATG7 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

NBR1 Rabbit Rabbit Polyclonal Antibody

ES8578-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against NBR1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

NBR1 Rabbit Rabbit Polyclonal Antibody

ES8578-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against NBR1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

NBR1 Rabbit Rabbit Polyclonal Antibody

ES8579-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against NBR1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

NBR1 Rabbit Rabbit Polyclonal Antibody

ES8579-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against NBR1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

Gab1 Rabbit Rabbit Polyclonal Antibody

ES8582-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Gab1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

Gab1 Rabbit Rabbit Polyclonal Antibody

ES8582-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Gab1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ERK1 Rabbit Rabbit Polyclonal Antibody

ES8583-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against ERK1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ERK1 Rabbit Rabbit Polyclonal Antibody

ES8583-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against ERK1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

PLEKHM2 sgRNA CRISPR Lentivector set (Human)

K1668101 3 x 1.0 ug
EUR 406.8

Plekhm2 sgRNA CRISPR Lentivector set (Mouse)

K3493501 3 x 1.0 ug
EUR 406.8

NM23A Rabbit Rabbit Polyclonal Antibody

ES8455-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against NM23A Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

NM23A Rabbit Rabbit Polyclonal Antibody

ES8455-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against NM23A Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

HSC70 Rabbit Rabbit Polyclonal Antibody

ES8558-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against HSC70 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

HSC70 Rabbit Rabbit Polyclonal Antibody

ES8558-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against HSC70 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

Our findings suggest that for the production of bispecific antibodies that can be advantageous to modify the strength of translational for the selected protein chain in order to improve overall yield and product quality. By extension, tuning translational force can also be applied to improve the production of various heterologous proteins. This article is protected by copyright. All rights reserved.

Evelyn

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