Exploring sample preparation and data evaluation strategies for enhanced identification of host cell proteins in drug products of therapeutic antibodies and Fc-fusion proteins

Exploring sample preparation and data evaluation strategies for enhanced identification of host cell proteins in drug products of therapeutic antibodies and Fc-fusion proteins

Biopharmaceutical manufacturing involves the expression of recombinant proteins in host cells followed by extensive purification of target proteins. However, the host cell protein (HCP) can survive in the final drug product, potentially reducing the quality with respect to safety and efficacy. As a result, residual HCP monitored closely during downstream processing techniques such as enzyme-linked immunosorbent assay (ELISA) or high performance liquid chromatography combined with tandem mass spectrometry (HPLC-MS / MS). The latter is particularly interesting because it provides information regarding the identity of proteins. Although applied HPLC-MS / MS methodology is often optimized with respect to the identification of HCP, the data obtained are usually analyzed using standard settings.

Here, we describe a strategy for evaluating improved HPLC-MS / MS Data HCP-derived peptide, which involves probabilistic inference of protein and peptide detection in the absence of a fragment ion spectra. This data analysis workflow is applied to the data obtained for various medicinal products in the protein biotherapeutics A affinity depletion. The strategy enabled evaluation of data presented in-depth comparative analysis of the repertoire HCP identified in the drug product and bevacizumab monoclonal antibody rituximab, as well as the fusion protein etanercept. Unlike the common ELISA strategy applied, the workflow here presented is a process-independent and can be implemented into existing HPLC-MS / MS setup for the drug product characterization and process development. abstract graphics.


Aggregation is an important parameter for protein-based therapies, the impact on the immunogenicity of the product. The traditional approach to the characterization of the product is to use a set of orthogonal tool. However, the fact that none of these tools is able to fully classify aggregate distribution and physical characteristics, implying that there is a need for additional analysis methods.

We report one such method for the characterization of a heterogeneous population of proteins using a transmission electron microscope. This method involves a semi-automatic, based on the size-species clustering of different proteins from the micrograph. This method can be used for quantitative characterization of aggregates heterogeneous population of antibody / protein of TEM images of protein, and may also apply to other cases of protein aggregation.

 Exploring sample preparation and data evaluation strategies for enhanced identification of host cell proteins in drug products of therapeutic antibodies and Fc-fusion proteins
Exploring sample preparation and data evaluation strategies for enhanced identification of host cell proteins in drug products of therapeutic antibodies and Fc-fusion proteins

Antibody serum level of Advanced Glycation End Products in Patients with Type 2 Diabetes Mellitus and Hypertension

Background and purpose: Protein contains advanced glycation end products highly immunogenic and anti-antibody advanced glycation end products (AGEs anti-antibody) found in the sera of patients with diabetes.


Materials and methods: Enzyme-linked immunosorbent assay (ELISA) was used to measure the level of glycation end products developed antibodies in sera from 93 patients with type 2 diabetes mellitus and arterial hypertension (mean age 61.4 ± 11.3 years, diabetes duration 3:12 ± 9.88 years; the duration of hypertension 9.28 ± 4.98). These values ​​compared with serum antibodies anti-AGEs in 42 age and sex matched controls. Diabetics were divided into two groups according to the presence or absence of microangiopathy, group 1 (n = 67) and group 2 (n = 26), respectively.

JMJD8 Polyclonal Antibody

27453-50ul 50ul
EUR 224.4

JMJD8 Polyclonal Conjugated Antibody

C27453 100ul
EUR 476.4

JMJD7 Rabbit Polyclonal Antibody

55207 100ul
EUR 439

JMJD7 Rabbit Polyclonal Antibody

E10G01491 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

JMJD6 Rabbit Polyclonal Antibody

E10G08453 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

JMJD7 Rabbit Polyclonal Antibody

E10G08454 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

JMJD1C Rabbit Polyclonal Antibody

54639 100ul
EUR 439

JMJD2B Rabbit Polyclonal Antibody

ES5294-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against JMJD2B from Human. This antibody is tested and validated for IHC, WB, ELISA

JMJD2B Rabbit Polyclonal Antibody

ES5294-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against JMJD2B from Human. This antibody is tested and validated for IHC, WB, ELISA

JMJD2C Rabbit Polyclonal Antibody

E10G33214 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

JMJD1C Rabbit Polyclonal Antibody

E10G33938 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Rabbit Polyclonal JMJD4 Antibody

TA306833 100 µg Ask for price

Rabbit Polyclonal JMJD5 Antibody

TA306834 100 µg Ask for price

Rabbit Polyclonal JMJD6 Antibody

TA306835 100 µg Ask for price

Rabbit Polyclonal JMJD7 Antibody

TA306836 100 µg Ask for price

Rabbit Polyclonal JMJD3 Antibody

TA309713 100 µl Ask for price

Rabbit Polyclonal JMJD3 Antibody

TA319844 100 µg Ask for price

Rabbit Polyclonal JMJD2a Antibody

TA347226 50 µg Ask for price

Rabbit Polyclonal JMJD2b Antibody

TA347227 100 µl Ask for price

Rabbit Polyclonal JMJD2c Antibody

TA347228 100 µl Ask for price

Rabbit Polyclonal JMJD1A Antibody

TA306828 100 µg Ask for price

Rabbit Polyclonal JMJD1B Antibody

TA306829 100 µg Ask for price

Rabbit Polyclonal JMJD1C Antibody

TA306830 100 µg Ask for price

Rabbit Polyclonal JMJD2A Antibody

TA306831 100 µg Ask for price

Rabbit Polyclonal JMJD2B Antibody

TA306832 100 µg Ask for price

Rabbit Polyclonal JMJD2C Antibody

TA309711 100 µl Ask for price

Rabbit Polyclonal JMJD2D Antibody

TA309712 100 µl Ask for price

Rabbit Polyclonal JMJD1C Antibody

TA590432 100 µg Ask for price

Rabbit Polyclonal JMJD6/PSR Antibody

TA336815 50 µl Ask for price

JMJD4 (N-term) Rabbit Polyclonal Antibody

E10G30177 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

JMJD5 (N-term) Rabbit Polyclonal Antibody

E10G33702 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Rabbit polyclonal JMJD3 Antibody (N-term)

TA324360 400 µl Ask for price

JMJD6 (PTDSR) (N-term) Rabbit Polyclonal Antibody

E10G33692 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

JMJD4 (N-term) rabbit polyclonal antibody, Purified

AP23900PU-N 50 µg Ask for price

JMJD4 (N-term) rabbit polyclonal antibody, Purified

AP11044PU-N 400 µl Ask for price

JMJD4 (C-term) rabbit polyclonal antibody, Purified

AP11045PU-N 400 µl Ask for price

JMJD6 (N-term) rabbit polyclonal antibody, Purified

AP11061PU-N 400 µl Ask for price

JMJD1C (N-term) rabbit polyclonal antibody, Purified

AP23898PU-N 50 µg Ask for price

Rabbit polyclonal anti-JHD3B (KDM4B / JMJD2B) antibody

TA312718 100 µl Ask for price

JMJD5 (KDM8) (C-term) rabbit polyclonal antibody, Purified

AP23901PU-N 50 µg Ask for price

JMJD5 (KDM8) (N-term) rabbit polyclonal antibody, Aff - Purified

AP52273PU-N 400 µl Ask for price

Rabbit Polyclonal Anti-JMJD8 Antibody

TA329722 100 µl Ask for price

Rabbit Polyclonal Lysine (K)-specific Demethylase 3A/KDM3A/JMJD1A Antibody

TA336794 100 µl Ask for price

Rabbit Polyclonal Lysine (K)-specific Demethylase 4A/KDM4A/JMJD2A Antibody

TA336795 100 µl Ask for price

Rabbit Polyclonal Anti-JMJD8 Antibody - middle region

TA344415 100 µl Ask for price

JMJD8 Rabbit pAb

A10476-100ul 100 ul
EUR 369.6

JMJD8 Rabbit pAb

A10476-200ul 200 ul
EUR 550.8

JMJD8 Rabbit pAb

A10476-20ul 20 ul
EUR 219.6

JMJD8 Rabbit pAb

A10476-50ul 50 ul
EUR 267.6

JMJD8 Rabbit pAb

E2510476 100ul
EUR 225
Description: Available in various conjugation types.

Polyclonal JMJD2c polyclonal antibody

APR00375G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JMJD2c polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal JMJD2c polyclonal antibody

APR00450G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JMJD2c polyclonal . This antibody is tested and proven to work in the following applications:

JMJD4 Polyclonal Antibody

31407 100ul
EUR 439

JMJD4 Polyclonal Antibody

31407-100ul 100ul
EUR 302.4

JMJD4 Polyclonal Antibody

31407-50ul 50ul
EUR 224.4

JMJD7 Polyclonal Antibody

E97408 100ul
EUR 225
Description: Available in various conjugation types.

JMJD6 Polyclonal Antibody

A-3724
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 µl
  • 50 ul
  • 100 ul

JMJD6 Polyclonal Antibody

E-AB-92435-120uL 120uL
EUR 320
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-92435-200uL 200uL
EUR 530
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-92435-60uL 60uL
EUR 200
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-92435-each each Ask for price
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-15147-120uL 120uL
EUR 240
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-15147-200uL 200uL
EUR 399
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-15147-20uL 20uL
EUR 73
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-15147-60uL 60uL
EUR 143
Description: Unconjugated

JMJD7 Polyclonal Antibody

E-AB-67865-120uL 120uL
EUR 320
Description: Unconjugated

JMJD7 Polyclonal Antibody

E-AB-67865-200uL 200uL
EUR 530
Description: Unconjugated

JMJD7 Polyclonal Antibody

E-AB-67865-60uL 60uL
EUR 200
Description: Unconjugated

JMJD7 Polyclonal Antibody

E-AB-67865-each each Ask for price
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-70209-120uL 120uL
EUR 260
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-70209-200uL 200uL
EUR 410
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-70209-60uL 60uL
EUR 160
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-70209-each each Ask for price
Description: Unconjugated

JMJD4 Polyclonal Antibody

E-AB-62516-120uL 120uL
EUR 320
Description: Unconjugated

JMJD4 Polyclonal Antibody

E-AB-62516-200uL 200uL
EUR 530
Description: Unconjugated

JMJD4 Polyclonal Antibody

E-AB-62516-60uL 60uL
EUR 200
Description: Unconjugated

JMJD4 Polyclonal Antibody

E-AB-62516-each each Ask for price
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-61144-120uL 120uL
EUR 320
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-61144-200uL 200uL
EUR 530
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-61144-60uL 60uL
EUR 200
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-61144-each each Ask for price
Description: Unconjugated

JMJD2B Polyclonal Antibody

ABP54295-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of JMJD2B from Human. This JMJD2B antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human JMJD2B at AA rangle: 320-400

JMJD2B Polyclonal Antibody

ABP54295-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of JMJD2B from Human. This JMJD2B antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human JMJD2B at AA rangle: 320-400

JMJD2B Polyclonal Antibody

ABP54295-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of JMJD2B from Human. This JMJD2B antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human JMJD2B at AA rangle: 320-400

JMJD2a polyclonal antibody

6851-25 each
EUR 301.2

JMJD2b polyclonal antibody

6852-50 each
EUR 444

JMJD2c polyclonal antibody

6853-50 each
EUR 301.2

JMJD2B Polyclonal Antibody

E20-72437 100ug
EUR 225
Description: Available in various conjugation types.

JMJD2B Polyclonal Antibody

E44H05100 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

JMJD1C Polyclonal Antibody

E-AB-92173-120uL 120uL
EUR 320
Description: Unconjugated

JMJD1C Polyclonal Antibody

E-AB-92173-200uL 200uL
EUR 530
Description: Unconjugated

JMJD1C Polyclonal Antibody

E-AB-92173-60uL 60uL
EUR 200
Description: Unconjugated

JMJD1C Polyclonal Antibody

E-AB-92173-each each Ask for price
Description: Unconjugated

Polyclonal JMJD5 Antibody

APR06564G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JMJD5 . This antibody is tested and proven to work in the following applications:

Polyclonal JMJD6 Antibody

APR06565G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JMJD6 . This antibody is tested and proven to work in the following applications:

Polyclonal JMJD7 Antibody

APR06566G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JMJD7 . This antibody is tested and proven to work in the following applications:

Polyclonal JMJD6 Antibody

APR00328G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JMJD6 . This antibody is tested and proven to work in the following applications:

Polyclonal JMJD1B Antibody

APR06563G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JMJD1B . This antibody is tested and proven to work in the following applications:

JMJD8 Antibody

5387-002mg 0.02 mg
EUR 206.18
Description: JMJD8 Antibody: The jumonji domain-containing protein (JMJD) family is defined by the presence of the JmjC domain that is observed in several diverse species. While several JMJD proteins have been identified as being involved in chromatin regulation, histone demethylation and development, the function of JMJD8 has not been identified.

JMJD8 Antibody

5387-01mg 0.1 mg
EUR 523.7
Description: JMJD8 Antibody: The jumonji domain-containing protein (JMJD) family is defined by the presence of the JmjC domain that is observed in several diverse species. While several JMJD proteins have been identified as being involved in chromatin regulation, histone demethylation and development, the function of JMJD8 has not been identified.

JMJD8 Antibody

24964 100ul
EUR 479

JMJD8 Antibody

24964-100ul 100ul
EUR 468

JMJD8 Antibody

DF15559 100ul
EUR 420

JMJD8 Antibody

DF15559-100ul 100ul
EUR 280

JMJD8 Antibody

DF15559-200ul 200ul
EUR 350

JMJD8 Antibody

E910476 100ul
EUR 255
Description: Available in various conjugation types.

Jmjd8 antibody

70R-9594 50 ug
EUR 467
Description: Affinity purified rabbit polyclonal Jmjd8 antibody

JMJD8 Antibody

GWB-13FA88 0.05 mg Ask for price

Jmjd8 Antibody

GWB-MV164B 50ug Ask for price

JMJD8 Antibody

GWB-MV165C 50ug Ask for price

Polyclonal JMJD5 Antibody (N-term)

APR03509G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JMJD5 (N-term). This antibody is tested and proven to work in the following applications:

Polyclonal JMJD2C Antibody (C-term)

APR03565G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JMJD2C (C-term). This antibody is tested and proven to work in the following applications:

JMJD4 Polyclonal Conjugated Antibody

C31407 100ul
EUR 476.4

Polyclonal JMJD6 / PSR Antibody (aa127-144)

APR02898G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JMJD6 / PSR (aa127-144). This antibody is tested and proven to work in the following applications:

Polyclonal KDM3B / JMJD1B Antibody (Internal)

APR02708G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human KDM3B / JMJD1B (Internal). This antibody is tested and proven to work in the following applications:

Rabbit Polyclonal AntibodyPC1 Rabbit Polyclonal Antibody

53940 100ul
EUR 439

Rabbit Polyclonal AntibodyPC4 Rabbit Polyclonal Antibody

54946 100ul
EUR 439

Rabbit Anti JMJD6 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4) (IHC)

IRBAMLJMJD6AP209120UL each
EUR 281
Description: Rabbit Anti JMJD6 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4) (IHC)

Rabbit Anti JMJD6 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4) (IHC)

IRBAMLJMJD6AP209200UL each
EUR 394
Description: Rabbit Anti JMJD6 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4) (IHC)

Rabbit Polyclonal Anti-BAG4 rabbit polyclonal antibody

TA351743 100 µl Ask for price

Rabbit Polyclonal Anti-LPP rabbit polyclonal antibody

TA351364 100 µl Ask for price

Rabbit Polyclonal Anti-TPR rabbit polyclonal antibody

TA351467 100 µl Ask for price

Rabbit Polyclonal Anti-RORA rabbit polyclonal antibody

TA351609 100 µl Ask for price

Rabbit Polyclonal Anti-SSX5 rabbit polyclonal antibody

TA351758 100 µl Ask for price

Rabbit Polyclonal Anti-TGM7 rabbit polyclonal antibody

TA351848 100 µl Ask for price

Rabbit Polyclonal Anti-NOX5 rabbit polyclonal antibody

TA350234 100 µl Ask for price

Rabbit Polyclonal Anti-SRPX rabbit polyclonal antibody

TA350419 100 µl Ask for price

Rabbit Polyclonal Anti-STX7 rabbit polyclonal antibody

TA350469 100 µl Ask for price

Rabbit Polyclonal Anti-STX8 rabbit polyclonal antibody

TA350470 100 µl Ask for price

Rabbit Anti JMJD6 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Western Blot,IHC)

IRBAMLJMJD6AP144120UL each
EUR 346
Description: Rabbit Anti JMJD6 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Western Blot,IHC)

Rabbit Anti JMJD6 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Western Blot,IHC)

IRBAMLJMJD6AP144200UL each
EUR 509
Description: Rabbit Anti JMJD6 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Western Blot,IHC)

Rabbit Polyclonal Anti-CERS3 rabbit polyclonal antibody

TA351342 100 µl Ask for price

Rabbit Polyclonal Anti-LLGL2 rabbit polyclonal antibody

TA351357 100 µl Ask for price

Rabbit Polyclonal Anti-PSMB8 rabbit polyclonal antibody

TA351358 100 µl Ask for price

Rabbit Polyclonal Anti-LONP1 rabbit polyclonal antibody

TA351359 100 µl Ask for price

Rabbit Polyclonal Anti-LOXL2 rabbit polyclonal antibody

TA351360 100 µl Ask for price

Rabbit Polyclonal Anti-LOXL3 rabbit polyclonal antibody

TA351362 100 µl Ask for price

Rabbit Polyclonal Anti-LOXL4 rabbit polyclonal antibody

TA351363 100 µl Ask for price

Rabbit Polyclonal Anti-LZTS1 rabbit polyclonal antibody

TA351367 100 µl Ask for price

Rabbit Polyclonal Anti-MACC1 rabbit polyclonal antibody

TA351368 100 µl Ask for price

Rabbit Polyclonal Anti-SMYD5 rabbit polyclonal antibody

TA351731 100 µl Ask for price

Rabbit Polyclonal Anti-TRPV5 rabbit polyclonal antibody

TA351861 100 µl Ask for price

Rabbit Polyclonal Anti-TRPV3 rabbit polyclonal antibody

TA351862 100 µl Ask for price

Rabbit Polyclonal Anti-SPARC rabbit polyclonal antibody

TA349441 100 µl Ask for price

Rabbit Polyclonal Anti-OLFM3 rabbit polyclonal antibody

TA350251 100 µl Ask for price

Rabbit Polyclonal Anti-OLFM4 rabbit polyclonal antibody

TA350252 100 µl Ask for price

Rabbit Polyclonal Anti-ROBO4 rabbit polyclonal antibody

TA350367 100 µl Ask for price

Rabbit Polyclonal Anti-RRAGA rabbit polyclonal antibody

TA350374 100 µl Ask for price

Rabbit Polyclonal Anti-SAMD7 rabbit polyclonal antibody

TA350388 100 µl Ask for price

Rabbit Polyclonal Anti-SEPP1 rabbit polyclonal antibody

TA350395 100 µl Ask for price

Rabbit Polyclonal Anti-SENP8 rabbit polyclonal antibody

TA350399 100 µl Ask for price

Rabbit Polyclonal Anti-SENP5 rabbit polyclonal antibody

TA350400 100 µl Ask for price

Rabbit Polyclonal Anti-SMYD3 rabbit polyclonal antibody

TA350428 100 µl Ask for price

Rabbit Polyclonal Anti-SMYD4 rabbit polyclonal antibody

TA350429 100 µl Ask for price

Rabbit Polyclonal Anti-SNAI3 rabbit polyclonal antibody

TA350430 100 µl Ask for price

Rabbit Polyclonal Anti-STX18 rabbit polyclonal antibody

TA350473 100 µl Ask for price

Rabbit Polyclonal Anti-STX11 rabbit polyclonal antibody

TA350476 100 µl Ask for price

Rabbit Polyclonal Anti-STX19 rabbit polyclonal antibody

TA350477 100 µl Ask for price

Rabbit Polyclonal Anti-TBX18 rabbit polyclonal antibody

TA350485 100 µl Ask for price

Rabbit Polyclonal Anti-TBX10 rabbit polyclonal antibody

TA350486 100 µl Ask for price

Rabbit Polyclonal Anti-EFNB3 rabbit polyclonal antibody

TA350660 100 µl Ask for price

Rabbit Polyclonal Anti-FOXG1 rabbit polyclonal antibody

TA350672 100 µl Ask for price

Polyclonal KDM8 / JMJD5 / FLJ13798 Antibody (C-Terminus)

APR02709G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human KDM8 / JMJD5 / FLJ13798 (C-Terminus). This antibody is tested and proven to work in the following applications:

Rabbit Polyclonal Anti-LTB4R2 rabbit polyclonal antibody

TA351366 100 µl Ask for price

Rabbit Polyclonal Anti-AGPAT9 rabbit polyclonal antibody

TA351369 100 µl Ask for price

Rabbit Polyclonal Anti-MAGEB2 rabbit polyclonal antibody

TA351371 100 µl Ask for price

Rabbit Polyclonal Anti-SLC7A5 rabbit polyclonal antibody

TA351714 100 µl Ask for price

Rabbit Polyclonal Anti-AGPAT6 rabbit polyclonal antibody

TA351863 100 µl Ask for price

Rabbit Polyclonal Anti-PRSS50 rabbit polyclonal antibody

TA351865 100 µl Ask for price

Rabbit Polyclonal Anti-PTPMT1 rabbit polyclonal antibody

TA350308 100 µl Ask for price

Rabbit Polyclonal Anti-DHCR24 rabbit polyclonal antibody

TA350394 100 µl Ask for price

Rabbit Polyclonal Anti-SEMA4A rabbit polyclonal antibody

TA350396 100 µl Ask for price

Rabbit Polyclonal Anti-TRIM21 rabbit polyclonal antibody

TA350447 100 µl Ask for price

Rabbit Polyclonal Anti-STXBP4 rabbit polyclonal antibody

TA350474 100 µl Ask for price

Rabbit Polyclonal Anti-MAGEA11 rabbit polyclonal antibody

TA351370 100 µl Ask for price

Rabbit Polyclonal Anti-SLC16A9 rabbit polyclonal antibody

TA351677 100 µl Ask for price

Rabbit Polyclonal Anti-SLC24A6 rabbit polyclonal antibody

TA351684 100 µl Ask for price

Rabbit Polyclonal Anti-SLC17A1 rabbit polyclonal antibody

TA351718 100 µl Ask for price

Rabbit Polyclonal Anti-S100A14 rabbit polyclonal antibody

TA350383 100 µl Ask for price

Rabbit Polyclonal Anti-SH3KBP1 rabbit polyclonal antibody

TA350412 100 µl Ask for price

Rabbit Polyclonal Anti-SERPINB1 rabbit polyclonal antibody

TA350405 100 µl Ask for price

Rabbit Polyclonal Anti-SERPINB6 rabbit polyclonal antibody

TA350406 100 µl Ask for price

Rabbit Polyclonal Anti-SERPINB8 rabbit polyclonal antibody

TA350407 100 µl Ask for price

Rabbit Polyclonal Anti-SIGLEC12 rabbit polyclonal antibody

TA350415 100 µl Ask for price

Rabbit Polyclonal Anti-SLC25A26 rabbit polyclonal antibody

TA350422 100 µl Ask for price

Polyclonal AntibodyP3 Rabbit Polyclonal Antibody

ES6454-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against P3 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Polyclonal AntibodyP3 Rabbit Polyclonal Antibody

ES6454-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against P3 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Polyclonal AntibodyP1 Rabbit Polyclonal Antibody

ES11752-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against P1. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP1 Rabbit Polyclonal Antibody

ES11752-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against P1. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP5 Rabbit Polyclonal Antibody

ES4829-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against P5 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA


Results:
The serum levels of anti-AGEs antibody in patients with type 2 diabetes mellitus and arterial hypertension was statistically significantly higher than the control group (1.39 ± 0.39 vs 1.05 ± 0.32) (p <0, 05). Group 1 showed significantly higher levels of antibodies anti-AGEs compared to healthy controls (1.53 ± 0.14 vs 1.05 ± 0.32) (p <0.01).

Evelyn

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