Exploring sample preparation and data evaluation strategies for enhanced identification of host cell proteins in drug products of therapeutic antibodies and Fc-fusion proteins

Exploring sample preparation and data evaluation strategies for enhanced identification of host cell proteins in drug products of therapeutic antibodies and Fc-fusion proteins

Biopharmaceutical manufacturing involves the expression of recombinant proteins in host cells followed by extensive purification of target proteins. However, the host cell protein (HCP) can survive in the final drug product, potentially reducing the quality with respect to safety and efficacy. As a result, residual HCP monitored closely during downstream processing techniques such as enzyme-linked immunosorbent assay (ELISA) or high performance liquid chromatography combined with tandem mass spectrometry (HPLC-MS / MS). The latter is particularly interesting because it provides information regarding the identity of proteins. Although applied HPLC-MS / MS methodology is often optimized with respect to the identification of HCP, the data obtained are usually analyzed using standard settings.

Here, we describe a strategy for evaluating improved HPLC-MS / MS Data HCP-derived peptide, which involves probabilistic inference of protein and peptide detection in the absence of a fragment ion spectra. This data analysis workflow is applied to the data obtained for various medicinal products in the protein biotherapeutics A affinity depletion. The strategy enabled evaluation of data presented in-depth comparative analysis of the repertoire HCP identified in the drug product and bevacizumab monoclonal antibody rituximab, as well as the fusion protein etanercept. Unlike the common ELISA strategy applied, the workflow here presented is a process-independent and can be implemented into existing HPLC-MS / MS setup for the drug product characterization and process development. abstract graphics.


Aggregation is an important parameter for protein-based therapies, the impact on the immunogenicity of the product. The traditional approach to the characterization of the product is to use a set of orthogonal tool. However, the fact that none of these tools is able to fully classify aggregate distribution and physical characteristics, implying that there is a need for additional analysis methods.

We report one such method for the characterization of a heterogeneous population of proteins using a transmission electron microscope. This method involves a semi-automatic, based on the size-species clustering of different proteins from the micrograph. This method can be used for quantitative characterization of aggregates heterogeneous population of antibody / protein of TEM images of protein, and may also apply to other cases of protein aggregation.

 Exploring sample preparation and data evaluation strategies for enhanced identification of host cell proteins in drug products of therapeutic antibodies and Fc-fusion proteins
Exploring sample preparation and data evaluation strategies for enhanced identification of host cell proteins in drug products of therapeutic antibodies and Fc-fusion proteins

Antibody serum level of Advanced Glycation End Products in Patients with Type 2 Diabetes Mellitus and Hypertension

Background and purpose: Protein contains advanced glycation end products highly immunogenic and anti-antibody advanced glycation end products (AGEs anti-antibody) found in the sera of patients with diabetes.


Materials and methods: Enzyme-linked immunosorbent assay (ELISA) was used to measure the level of glycation end products developed antibodies in sera from 93 patients with type 2 diabetes mellitus and arterial hypertension (mean age 61.4 ± 11.3 years, diabetes duration 3:12 ± 9.88 years; the duration of hypertension 9.28 ± 4.98). These values ​​compared with serum antibodies anti-AGEs in 42 age and sex matched controls. Diabetics were divided into two groups according to the presence or absence of microangiopathy, group 1 (n = 67) and group 2 (n = 26), respectively.

JMJD8 Polyclonal Antibody

27453-50ul 50ul
EUR 224.4

JMJD8 Polyclonal Antibody

MBS9130977-002mL 0.02mL
EUR 200

JMJD8 Polyclonal Antibody

MBS9130977-005mL 0.05mL
EUR 255

JMJD8 Polyclonal Antibody

MBS9130977-01mL 0.1mL
EUR 345

JMJD8 Polyclonal Antibody

MBS9130977-02mL 0.2mL
EUR 545

JMJD8 Polyclonal Antibody

MBS9130977-5x02mL 5x0.2mL
EUR 2265

JMJD8 Polyclonal Antibody

MBS2547707-006mL 0.06mL
EUR 180

JMJD8 Polyclonal Antibody

MBS2547707-012mL 0.12mL
EUR 260

JMJD8 Polyclonal Antibody

MBS2547707-02mL 0.2mL
EUR 405

JMJD8 Polyclonal Antibody

MBS2547707-5x02mL 5x0.2mL
EUR 1725

JMJD8 Polyclonal Antibody

MBS9431329-005mL 0.05mL
EUR 300

JMJD8 Polyclonal Antibody

MBS9431329-01mL 0.1mL
EUR 390

JMJD8 Polyclonal Antibody

MBS9431329-5x01mL 5x0.1mL
EUR 1610

JMJD8 Polyclonal Conjugated Antibody

C27453 100ul
EUR 476.4

JMJD8 Polyclonal Conjugated Antibody

MBS9439344-01mLAF350 0.1mL(AF350)
EUR 480

JMJD8 Polyclonal Conjugated Antibody

MBS9439344-01mLAF405 0.1mL(AF405)
EUR 480

JMJD8 Polyclonal Conjugated Antibody

MBS9439344-01mLAF488 0.1mL(AF488)
EUR 480

JMJD8 Polyclonal Conjugated Antibody

MBS9439344-01mLAF555 0.1mL(AF555)
EUR 480

JMJD8 Polyclonal Conjugated Antibody

MBS9439344-01mLBiotin 0.1mL(Biotin)
EUR 480

JMJD7 Rabbit Polyclonal Antibody

55207 100ul
EUR 439

JMJD7 Rabbit Polyclonal Antibody

E10G01491 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

JMJD6 Rabbit Polyclonal Antibody

E10G08453 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

JMJD7 Rabbit Polyclonal Antibody

E10G08454 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

JMJD4 Rabbit Polyclonal Antibody

BT-AP03183-100ul 100ul Ask for price

JMJD4 Rabbit Polyclonal Antibody

BT-AP03183-20ul 20ul Ask for price

JMJD4 Rabbit Polyclonal Antibody

BT-AP03183-50ul 50ul Ask for price

JMJD7 Rabbit Polyclonal Antibody

MBS9466238-005mL 0.05mL
EUR 300

JMJD7 Rabbit Polyclonal Antibody

MBS9466238-01mL 0.1mL
EUR 390

JMJD7 Rabbit Polyclonal Antibody

MBS9466238-5x01mL 5x0.1mL
EUR 1610

JMJD1C Rabbit Polyclonal Antibody

54639 100ul
EUR 439

JMJD2B Rabbit Polyclonal Antibody

ES5294-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against JMJD2B from Human. This antibody is tested and validated for IHC, WB, ELISA

JMJD2B Rabbit Polyclonal Antibody

ES5294-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against JMJD2B from Human. This antibody is tested and validated for IHC, WB, ELISA

JMJD2C Rabbit Polyclonal Antibody

E10G33214 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

JMJD1C Rabbit Polyclonal Antibody

E10G33938 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

JMJD1C Rabbit Polyclonal Antibody

MBS9467749-005mL 0.05mL
EUR 300

JMJD1C Rabbit Polyclonal Antibody

MBS9467749-01mL 0.1mL
EUR 390

JMJD1C Rabbit Polyclonal Antibody

MBS9467749-5x01mL 5x0.1mL
EUR 1610

Rabbit Polyclonal JMJD4 Antibody

TA306833 100 µg Ask for price

Rabbit Polyclonal JMJD5 Antibody

TA306834 100 µg Ask for price

Rabbit Polyclonal JMJD6 Antibody

TA306835 100 µg Ask for price

Rabbit Polyclonal JMJD7 Antibody

TA306836 100 µg Ask for price

Rabbit Polyclonal JMJD3 Antibody

TA309713 100 µl Ask for price

Rabbit Polyclonal JMJD3 Antibody

TA319844 100 µg Ask for price

Rabbit Polyclonal JMJD2a Antibody

TA347226 50 µg Ask for price

Rabbit Polyclonal JMJD2b Antibody

TA347227 100 µl Ask for price

Rabbit Polyclonal JMJD2c Antibody

TA347228 100 µl Ask for price

Rabbit Polyclonal JMJD1A Antibody

TA306828 100 µg Ask for price

Rabbit Polyclonal JMJD1B Antibody

TA306829 100 µg Ask for price

Rabbit Polyclonal JMJD1C Antibody

TA306830 100 µg Ask for price

Rabbit Polyclonal JMJD2A Antibody

TA306831 100 µg Ask for price

Rabbit Polyclonal JMJD2B Antibody

TA306832 100 µg Ask for price

Rabbit Polyclonal JMJD2C Antibody

TA309711 100 µl Ask for price

Rabbit Polyclonal JMJD2D Antibody

TA309712 100 µl Ask for price

Rabbit Polyclonal JMJD1C Antibody

TA590432 100 µg Ask for price

Rabbit Polyclonal JMJD6/PSR Antibody

TA336815 50 µl Ask for price

JMJD4 (N-term) Rabbit Polyclonal Antibody

E10G30177 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

JMJD5 (N-term) Rabbit Polyclonal Antibody

E10G33702 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Rabbit polyclonal JMJD3 Antibody (N-term)

TA324360 400 µl Ask for price

JMJD6 (PTDSR) (N-term) Rabbit Polyclonal Antibody

E10G33692 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Anti-KDM4B/JMJD2B Antibody, Rabbit Polyclonal

MBS8110359-01mL 0.1mL
EUR 300

Anti-KDM4B/JMJD2B Antibody, Rabbit Polyclonal

MBS8110359-5x01mL 5x0.1mL
EUR 1200

JMJD4 (N-term) rabbit polyclonal antibody, Purified

AP23900PU-N 50 µg Ask for price

JMJD4 (N-term) rabbit polyclonal antibody, Purified

AP11044PU-N 400 µl Ask for price

JMJD4 (C-term) rabbit polyclonal antibody, Purified

AP11045PU-N 400 µl Ask for price

JMJD6 (N-term) rabbit polyclonal antibody, Purified

AP11061PU-N 400 µl Ask for price

JMJD1C (N-term) rabbit polyclonal antibody, Purified

AP23898PU-N 50 µg Ask for price

Rabbit polyclonal anti-JHD3B (KDM4B / JMJD2B) antibody

TA312718 100 µl Ask for price

JMJD5 (KDM8) (C-term) rabbit polyclonal antibody, Purified

AP23901PU-N 50 µg Ask for price

Rabbit Polyclonal Anti-JMJD8 Antibody

TA329722 100 µl Ask for price

JMJD5 (KDM8) (N-term) rabbit polyclonal antibody, Aff - Purified

AP52273PU-N 400 µl Ask for price

Rabbit anti-Homo sapiens (Human) JMJD7 Polyclonal Antibody

MBS7139981-INQUIRE INQUIRE Ask for price

Rabbit anti-Caenorhabditis elegans jmjd-3.1 Polyclonal Antibody

MBS7187144-INQUIRE INQUIRE Ask for price

Rabbit anti-Caenorhabditis elegans jmjd-1.2 Polyclonal Antibody

MBS9006984-INQUIRE INQUIRE Ask for price

Rabbit anti-Caenorhabditis elegans jmjd-2 Polyclonal Antibody

MBS9013285-INQUIRE INQUIRE Ask for price

JMJD8 Rabbit pAb

A10476-100ul 100 ul
EUR 369.6

JMJD8 Rabbit pAb

A10476-200ul 200 ul
EUR 550.8

JMJD8 Rabbit pAb

A10476-20ul 20 ul
EUR 219.6

JMJD8 Rabbit pAb

A10476-50ul 50 ul
EUR 267.6

JMJD8 Rabbit pAb

E2510476 100ul
EUR 225
Description: Available in various conjugation types.

JMJD8 Rabbit pAb

MBS8547916-01mL 0.1mL
EUR 305

JMJD8 Rabbit pAb

MBS8547916-01mLAF405L 0.1mL(AF405L)
EUR 565

JMJD8 Rabbit pAb

MBS8547916-01mLAF405S 0.1mL(AF405S)
EUR 565

JMJD8 Rabbit pAb

MBS8547916-01mLAF610 0.1mL(AF610)
EUR 565

JMJD8 Rabbit pAb

MBS8547916-01mLAF635 0.1mL(AF635)
EUR 565

JMJD8 Rabbit pAb

A10476 100μL
EUR 88.56

Rabbit Polyclonal Lysine (K)-specific Demethylase 3A/KDM3A/JMJD1A Antibody

TA336794 100 µl Ask for price

Rabbit Polyclonal Lysine (K)-specific Demethylase 4A/KDM4A/JMJD2A Antibody

TA336795 100 µl Ask for price

Rabbit anti-Danio rerio (Zebrafish)(Brachydanio rerio) JMJD6 Polyclonal Antibody

MBS7197943-INQUIRE INQUIRE Ask for price

Rabbit anti-Danio rerio (Zebrafish)(Brachydanio rerio) JMJD4 Polyclonal Antibody

MBS9016306-INQUIRE INQUIRE Ask for price

Rabbit Polyclonal Anti-JMJD8 Antibody - middle region

TA344415 100 µl Ask for price

Rabbit anti-human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 polyclonal Antibody(JMJD6)

MBS1497129-005mL 0.05mL
EUR 190

Rabbit anti-human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 polyclonal Antibody(JMJD6)

MBS1497129-01mL 0.1mL
EUR 270

Rabbit anti-human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 polyclonal Antibody(JMJD6)

MBS1497129-5x01mL 5x0.1mL
EUR 1205

JMJD8 Antibody

5387-002mg 0.02 mg
EUR 206.18
Description: JMJD8 Antibody: The jumonji domain-containing protein (JMJD) family is defined by the presence of the JmjC domain that is observed in several diverse species. While several JMJD proteins have been identified as being involved in chromatin regulation, histone demethylation and development, the function of JMJD8 has not been identified.

JMJD8 Antibody

5387-01mg 0.1 mg
EUR 523.7
Description: JMJD8 Antibody: The jumonji domain-containing protein (JMJD) family is defined by the presence of the JmjC domain that is observed in several diverse species. While several JMJD proteins have been identified as being involved in chromatin regulation, histone demethylation and development, the function of JMJD8 has not been identified.

JMJD8 Antibody

24964 100ul
EUR 479

JMJD8 Antibody

24964-100ul 100ul
EUR 468

JMJD8 Antibody

DF15559 100ul
EUR 420

JMJD8 Antibody

DF15559-100ul 100ul
EUR 280

JMJD8 Antibody

DF15559-200ul 200ul
EUR 350

JMJD8 Antibody

E910476 100ul
EUR 255
Description: Available in various conjugation types.

Jmjd8 antibody

70R-9594 50 ug
EUR 467
Description: Affinity purified rabbit polyclonal Jmjd8 antibody

JMJD8 Antibody

GWB-13FA88 0.05 mg Ask for price

Jmjd8 Antibody

GWB-MV164B 50ug Ask for price

JMJD8 Antibody

GWB-MV165C 50ug Ask for price

JMJD8 Antibody

MBS9404721-01mL 0.1mL
EUR 495

JMJD8 Antibody

MBS9404721-5x01mL 5x0.1mL
EUR 2075

JMJD8 Antibody

MBS150896-01mg 0.1mg
EUR 445

JMJD8 Antibody

MBS150896-5x01mg 5x0.1mg
EUR 1965

JMJD8 Antibody

MBS9630847-01mL 0.1mL
EUR 260

JMJD8 Antibody

MBS9630847-02mL 0.2mL
EUR 305

JMJD8 Antibody

MBS9630847-5x02mL 5x0.2mL
EUR 1220

JMJD8 Antibody

MBS9633230-1mg 1mg
EUR 375

JMJD8 Antibody

MBS9633230-5x1mg 5x1mg
EUR 1545

Polyclonal JMJD2c polyclonal antibody

APR00375G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JMJD2c polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal JMJD2c polyclonal antibody

APR00450G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JMJD2c polyclonal . This antibody is tested and proven to work in the following applications:

JMJD4 Polyclonal Antibody

31407-100ul 100ul
EUR 302.4

JMJD4 Polyclonal Antibody

31407-50ul 50ul
EUR 224.4

JMJD7 Polyclonal Antibody

E97408 100ul
EUR 225
Description: Available in various conjugation types.

JMJD6 Polyclonal Antibody

A-3724
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  • Ask for price
  • Ask for price
  • 100 µl
  • 50 ul
  • 100 ul

JMJD6 Polyclonal Antibody

E-AB-92435-120uL 120uL
EUR 320
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-92435-200uL 200uL
EUR 530
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-92435-60uL 60uL
EUR 200
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-92435-each each Ask for price
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-15147-120uL 120uL
EUR 240
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-15147-200uL 200uL
EUR 399
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-15147-20uL 20uL
EUR 73
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-15147-60uL 60uL
EUR 143
Description: Unconjugated

JMJD7 Polyclonal Antibody

E-AB-67865-120uL 120uL
EUR 320
Description: Unconjugated

JMJD7 Polyclonal Antibody

E-AB-67865-200uL 200uL
EUR 530
Description: Unconjugated

JMJD7 Polyclonal Antibody

E-AB-67865-60uL 60uL
EUR 200
Description: Unconjugated

JMJD7 Polyclonal Antibody

E-AB-67865-each each Ask for price
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-70209-120uL 120uL
EUR 260
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-70209-200uL 200uL
EUR 410
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-70209-60uL 60uL
EUR 160
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-70209-each each Ask for price
Description: Unconjugated

JMJD4 Polyclonal Antibody

E-AB-62516-120uL 120uL
EUR 320
Description: Unconjugated

JMJD4 Polyclonal Antibody

E-AB-62516-200uL 200uL
EUR 530
Description: Unconjugated

JMJD4 Polyclonal Antibody

E-AB-62516-60uL 60uL
EUR 200
Description: Unconjugated

JMJD4 Polyclonal Antibody

E-AB-62516-each each Ask for price
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-61144-120uL 120uL
EUR 320
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-61144-200uL 200uL
EUR 530
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-61144-60uL 60uL
EUR 200
Description: Unconjugated

JMJD6 Polyclonal Antibody

E-AB-61144-each each Ask for price
Description: Unconjugated

JMJD5 Polyclonal Antibody

MBS668117-0025mg 0.025mg
EUR 175

JMJD5 Polyclonal Antibody

MBS668117-01mg 0.1mg
EUR 325

JMJD5 Polyclonal Antibody

MBS668117-5x01mg 5x0.1mg
EUR 1465

JMJD7 Polyclonal Antibody

MBS9238840-01mL 0.1mL
EUR 415

JMJD7 Polyclonal Antibody

MBS9238840-5x01mL 5x0.1mL
EUR 1841

JMJD6 Polyclonal Antibody

MBS9126484-002mL 0.02mL
EUR 200

JMJD6 Polyclonal Antibody

MBS9126484-005mL 0.05mL
EUR 255

JMJD6 Polyclonal Antibody

MBS9126484-01mL 0.1mL
EUR 345

JMJD6 Polyclonal Antibody

MBS9126484-02mL 0.2mL
EUR 545

JMJD6 Polyclonal Antibody

MBS9126484-5x02mL 5x0.2mL
EUR 2265

JMJD4 Polyclonal Antibody

MBS9127933-002mL 0.02mL
EUR 200

JMJD4 Polyclonal Antibody

MBS9127933-005mL 0.05mL
EUR 255

JMJD4 Polyclonal Antibody

MBS9127933-01mL 0.1mL
EUR 345

JMJD4 Polyclonal Antibody

MBS9127933-02mL 0.2mL
EUR 545

JMJD4 Polyclonal Antibody

MBS9127933-5x02mL 5x0.2mL
EUR 2265

JMJD7 Polyclonal Antibody

MBS8573374-01mL 0.1mL
EUR 305

JMJD7 Polyclonal Antibody

MBS8573374-01mLAF405L 0.1mL(AF405L)
EUR 565

JMJD7 Polyclonal Antibody

MBS8573374-01mLAF405S 0.1mL(AF405S)
EUR 565

JMJD7 Polyclonal Antibody

MBS8573374-01mLAF610 0.1mL(AF610)
EUR 565

JMJD7 Polyclonal Antibody

MBS8573374-01mLAF635 0.1mL(AF635)
EUR 565

JMJD7 Polyclonal Antibody

MBS2566697-006mL 0.06mL
EUR 190

JMJD7 Polyclonal Antibody

MBS2566697-012mL 0.12mL
EUR 265

JMJD7 Polyclonal Antibody

MBS2566697-02mL 0.2mL
EUR 415

JMJD7 Polyclonal Antibody

MBS2566697-5x02mL 5x0.2mL
EUR 1835

JMJD7 Polyclonal Antibody

MBS2522885-002mL 0.02mL
EUR 140

JMJD7 Polyclonal Antibody

MBS2522885-006mL 0.06mL
EUR 180

JMJD7 Polyclonal Antibody

MBS2522885-012mL 0.12mL
EUR 260

JMJD7 Polyclonal Antibody

MBS2522885-02mL 0.2mL
EUR 405

JMJD4 Polyclonal Antibody

MBS2541043-006mL 0.06mL
EUR 190

JMJD4 Polyclonal Antibody

MBS2541043-012mL 0.12mL
EUR 265

JMJD4 Polyclonal Antibody

MBS2541043-02mL 0.2mL
EUR 415

JMJD4 Polyclonal Antibody

MBS2541043-5x02mL 5x0.2mL
EUR 1835

JMJD6 Polyclonal Antibody

MBS2556228-006mL 0.06mL
EUR 190

JMJD6 Polyclonal Antibody

MBS2556228-012mL 0.12mL
EUR 265

JMJD6 Polyclonal Antibody

MBS2556228-02mL 0.2mL
EUR 415

JMJD6 Polyclonal Antibody

MBS2556228-5x02mL 5x0.2mL
EUR 1835

JMJD6 Polyclonal Antibody

MBS2529951-002mL 0.02mL
EUR 135

JMJD6 Polyclonal Antibody

MBS2529951-006mL 0.06mL
EUR 190

JMJD6 Polyclonal Antibody

MBS2529951-012mL 0.12mL
EUR 265

JMJD6 Polyclonal Antibody

MBS2529951-02mL 0.2mL
EUR 415

JMJD6 Polyclonal Antibody

MBS2529951-5x02mL 5x0.2mL
EUR 1835

JMJD6 Polyclonal Antibody

MBS2525786-002mL 0.02mL
EUR 135

JMJD6 Polyclonal Antibody

MBS2525786-006mL 0.06mL
EUR 190

JMJD6 Polyclonal Antibody

MBS2525786-012mL 0.12mL
EUR 265

JMJD6 Polyclonal Antibody

MBS2525786-02mL 0.2mL
EUR 415

JMJD6 Polyclonal Antibody

MBS2525786-5x02mL 5x0.2mL
EUR 1835


Results:
The serum levels of anti-AGEs antibody in patients with type 2 diabetes mellitus and arterial hypertension was statistically significantly higher than the control group (1.39 ± 0.39 vs 1.05 ± 0.32) (p <0, 05). Group 1 showed significantly higher levels of antibodies anti-AGEs compared to healthy controls (1.53 ± 0.14 vs 1.05 ± 0.32) (p <0.01).

Evelyn

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